Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors.
Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors.
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DOI：
10.1084/jem.20042393
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发表时间：
2005-03-21
期刊：
影响因子：
--
通讯作者：
Vieira P
中科院分区：
文献类型：
--
作者：
Dias S;Silva H Jr;Cumano A;Vieira P
白介素-7（IL-7）促进了淋巴前体的存活和膨胀。 （CLP），在没有IL-7的情况下，生成的B细胞分化程序具有正常的T/NK分化潜力，但根据IL-7 - 缺陷小鼠的CLPS严重受损。与野生型CLP相比，早期的B细胞因子（EBF）和PAX5较低，但重要的是GATA-3。 7通过调节EBF表达来指导CLP的承诺。 CLP阶段的IL-7受体。
Interleukin-7 (IL-7) promotes survival and expansion of lymphoid precursors. We show here that, in addition, IL-7 has a fundamental role, as early as the stage of the multipotent (B/T/NK) common lymphoid progenitor (CLP), in maintaining the B cell differentiation program open. CLPs generated in the absence of IL-7 have normal T/NK differentiation potential, but severely impaired B potential. Accordingly, CLPs from IL-7–deficient mice express lower amounts of early B cell factor (EBF) and Pax5 than wild-type CLPs, but similar amounts of GATA-3. Importantly, induced overexpression of EBF is sufficient to restore the B potential in these cells. These results indicate that IL-7 directs commitment of CLPs by modulating EBF expression. This is the first example of a cytokine influencing lymphoid lineage commitment in multipotent progenitors and highlights the relevance of the expression of a functional IL-7 receptor at the CLP stage.
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DOI：
10.1111/j.1749-6632.1996.tb52687.x
发表时间：
1996-01-01
期刊：
INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE
影响因子：
--
作者：
Hawley, RG;Lieu, FHL;Hawley, TS
通讯作者：
Hawley, TS
影响因子：
32.4
作者：
Khaled, AR;Li, WQ;Durum, SK
通讯作者：
Durum, SK
影响因子：
20.3
作者：
Douagi, I;Colucci, F;Cumano, A
通讯作者：
Cumano, A
影响因子：
4.4
作者：
Goetz, CA;Harmon, IR;Farrar, MA
通讯作者：
Farrar, MA
影响因子：
32.4
作者：
Igarashi, H;Gregory, SC;Kincade, PW
通讯作者：
Kincade, PW