Mouse Models of Psoriasis: A Comprehensive Review.

Mouse Models of Psoriasis: A Comprehensive Review.
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牛皮癣的鼠标模型:全面评论。

DOI:
10.1016/j.jid.2021.06.019
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发表时间:
2022-03
影响因子:
6.5
通讯作者:
Ward, Nicole L.
Ward, Nicole L.
中科院分区:
医学1区
文献类型:
--
作者:
Gangwar, Roopesh Singh;Gudjonsson, Johann E.;Ward, Nicole L.

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过去三十年来,银屑病临床前动物模型的使用显着增加,每种模型都有独特的优点和局限性。一些模型可以更好地转化为人类疾病,并且许多模型为牛皮癣疾病的发病机制提供了独特的见解。在这篇综合综述中,我们对遗传小鼠模型、异种移植方法以及使用细胞因子注射到小鼠和局部咪喹莫特的引出方法进行了比较描述和讨论。我们提供了一份包含咪喹莫特或皮肤注射细胞因子的转基因动物的清单,并描述了这些操作的结果。这篇综述将为那些对银屑病小鼠模型感兴趣的人提供宝贵的资源。
The use of preclinical animal models of psoriasis has significantly increased over the last three decades, with each model having unique strengths and limitations. Some models translate better to human disease, and many have provided unique insight into psoriasis disease pathogenesis. In this comprehensive review we present comparative description and discussion of genetic mouse models, xenograft approaches, and elicited methods using cytokine injections into, and topical imiquimod onto mice. We provide an inclusive list of genetically modified animals that have had imiquimod applied to, or cytokines injected into their skin and describe the outcomes of these manipulations. This review will provide a valuable resource for those interested in working with psoriasis mouse models.
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