Donor-Recipient Weight Match in Pediatric Heart Transplantation: Liberalizing Weight Matching with Caution.
Donor-Recipient Weight Match in Pediatric Heart Transplantation: Liberalizing Weight Matching with Caution.
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DOI：
10.3390/jcdd9050148
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发表时间：
2022-05-07
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
作者：
(1)背景：为了扩大供体库，在心脏移植中倾向于使用更大的供体心脏。然而，关于扩大供体和受体重量比（DRWR）的可行性的数据。将本研究中或其他文献中引用的所有供受体体重比（DRWR）转换为（（供受体体重）/受体体重）× 100%计算的DRWR。我国小儿心脏移植（HTx）中仍缺乏> 30%的移植物。随着DRWR适宜范围进一步扩大至> 30%，潜在风险沿着增加，其上限仍有争议。(2)研究方法：根据DRWR（> 30%和≤ 30%），将2015年至2020年在我们中心接受HTx的78例儿科患者（年龄<18岁）分为两组。通过单变量分析和多变量分析总结和分析变量。采用Kaplan-Meier方法计算生存期和条件生存期。(3)结果：两组患者的1年、3年、5年生存率差异无统计学意义。(4)结论：DRWR扩大到> 30%对于中国儿童HTx是可以接受的。值得注意的是，将DRWR上限不断放宽至200%以上可用作止损选项，但应谨慎应用。
(1) Background: To expand the donor pool, greater donor hearts tended to be used in heart transplantation. However, the data about the feasibility of expanding the donor and recipient weight ratios (DRWRs. All donor and recipient weight ratio (DRWR) in this study or cited from other articles were converted to the DRWR calculated by ((donor weight-recipient weight)/recipient weight) × 100%.) to >30% was still scant in China’s pediatric heart transplantation (HTx). The potential risk increased along with the further expansion of the appropriate range of DRWR to >30% and its upper limit was still in debate. (2) Methods: Seventy-eight pediatric patients (age < 18 years) undergoing HTx between 2015 and 2020 at our center were divided into two groups based on the DRWR (>30% and ≤30%). Variables were summarized and analyzed via univariate analyses and multivariate analyses. A Kaplan-Meier methodology was used to calculate survival and conditional survival. (3) Results: No significant difference was found in one-year, three-year or five-year survival between the two groups. (4) Conclusions: The expansion of DRWR to >30% was acceptable for China’s pediatric HTx. Notably, continuously liberalizing of the upper DRWR boundary to more than 200% could be used as a stop-loss option but should be applied with caution.
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