Elevated serum levels of Wisteria floribunda agglutinin-positive human Mac-2 binding protein predict the development of hepatocellular carcinoma in hepatitis C patients.
Elevated serum levels of Wisteria floribunda agglutinin-positive human Mac-2 binding protein predict the development of hepatocellular carcinoma in hepatitis C patients.
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DOI：
10.1002/hep.27305
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发表时间：
2014-11
期刊：
影响因子：
13.5
通讯作者：
Yatsuhashi, Hiroshi
中科院分区：
文献类型：
--
作者：
Yamasaki, Kazumi;Tateyama, Masakuni;Abiru, Seigo;Komori, Atsumasa;Nagaoka, Shinya;Saeki, Akira;Hashimoto, Satoru;Sasaki, Ryu;Bekki, Shigemune;Kugiyama, Yuki;Miyazoe, Yuri;Kuno, Atsushi;Korenaga, Masaaki;Togayachi, Akira;Ocho, Makoto;Mizokami, Masashi;Narimatsu, Hisashi;Yatsuhashi, Hiroshi
紫藤凝集素阳性人 Mac-2 结合蛋白 (WFA+-M2BP) 最近被证明是一种肝纤维化糖生物标志物，具有独特的纤维化相关糖改变。我们评估了 WFA+-M2BP 预测丙型肝炎病毒 (HCV) 感染患者发生肝细胞癌 (HCC) 的能力。对707例入院的慢性HCV感染且无其他潜在危险因素的患者进行评估，以确定WFA+-M2BP预测HCC发展的能力；评估的因素包括年龄、性别、病毒载量、基因型、纤维化阶段、天冬氨酸和丙氨酸转氨酶水平、胆红素、白蛋白、血小板计数、甲胎蛋白（AFP）、WFA+-M2BP以及对干扰素（IFN）治疗的反应。血清WFA+-M2BP水平随着肝纤维化分期的进展而显着升高（P < 0.001）。在纤维化的每个独特阶段（F0-F1、F2、F3 和 F4），发生 HCC 的风险随着 WFA+-M2BP 的升高而增加。多变量分析确定年龄 > 57 岁、F4、AFP > 20 ng/mL、WFA+-M2BP ≥4 和 WFA+-M2BP 1-4 以及对 IFN 的反应（无治疗与持续病毒学反应）是发生 HCC 的独立危险因素。受试者工作特征曲线下的时间依赖性面积表明，WFA+-M2BP 检测预测 HCC 发展的诊断准确性比 AFP 更高。结论：除了肝活检之外，WFA+-M2BP 还可用作 HCC 发展风险的有用替代标志物。 （肝病学 2014；60：1563–1570）
The Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) was recently shown to be a liver fibrosis glycobiomarker with a unique fibrosis-related glycoalteration. We evaluated the ability of WFA+-M2BP to predict the development of hepatocellular carcinoma (HCC) in patients who were infected with the hepatitis C virus (HCV). A total of 707 patients who had been admitted to our hospital with chronic HCV infection without other potential risk factors were evaluated to determine the ability of WFA+-M2BP to predict the development of HCC; factors evaluated included age, sex, viral load, genotypes, fibrosis stage, aspartate and alanine aminotransferase levels, bilirubin, albumin, platelet count, alpha-fetoprotein (AFP), WFA+-M2BP, and the response to interferon (IFN) therapy. Serum WFA+-M2BP levels were significantly increased according to the progression of liver fibrosis stage (P < 0.001). In each distinctive stage of fibrosis (F0-F1, F2, F3, and F4), the risk of development of HCC was increased according to the elevation of WFA+-M2BP. Multivariate analysis identified age >57 years, F4, AFP >20 ng/mL, WFA+-M2BP ≥4, and WFA+-M2BP 1-4 as well as the response to IFN (no therapy vs. sustained virological response) as independent risk factors for the development of HCC. The time-dependent areas under the receiver operating characteristic curve demonstrated that the WFA+-M2BP assay predicted the development of HCC with higher diagnostic accuracy than AFP. Conclusion: WFA+-M2BP can be applied as a useful surrogate marker for the risk of HCC development, in addition to liver biopsy. (Hepatology 2014;60:1563–1570)
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影响因子：
3.7
作者：
Narimatsu Y;Kuno A;Ito H;Kaji H;Kaneko S;Usui J;Yamagata K;Narimatsu H
通讯作者：
Narimatsu H
影响因子：
29.4
作者：
Liang, TJ;Heller, T
通讯作者：
Heller, T
影响因子：
13.5
作者：
Bedossa, P;Dargère, D;Paradis, V
通讯作者：
Paradis, V
影响因子：
2
作者：
Kuno, Atsushi;Sato, Takashi;Narimatsu, Hisashi
通讯作者：
Narimatsu, Hisashi
影响因子：
2.5
作者：
Cheung, K. J.;Tilleman, K.;Van Vlierberghe, H.
通讯作者：
Van Vlierberghe, H.