Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice.
Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice.
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DOI：
10.1016/j.neurobiolaging.2021.01.012
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发表时间：
2021-05
影响因子：
4.2
通讯作者：
Arnold WD
中科院分区：
文献类型：
--
作者：
Chugh D;Iyer CC;Bobbili P;Blatnik AJ 3rd;Kaspar BK;Meyer K;Burghes AH;Clark BC;Arnold WD
Sarcopenia, or pathological loss of muscle mass and strength during aging, is an important contributor to loss of physical function in older adults. Sarcopenia is a multifactorial syndrome associated with intrinsic muscle and upstream neurological dysfunction. Exercise is well-established as an effective intervention for sarcopenia, but less is known about the long-term neurobiological impact of exercise. The goals of this study were to investigate the effects of exercise, alone or in combination with follistatin (FST) overexpression (antagonist of myostatin), on neuromuscular junction transmission and motor unit numbers in mice between the age of 22 and 27 months, ages at which prior studies have demonstrated that some motor unit loss is already evident. C57BL/6J mice underwent baseline assessment and were randomized to housing with or without voluntary running wheels and injection with adeno-associated virus to overexpress FST or vehicle. Groups for comparison included sedentary and running with and without FST. Longitudinal assessments showed significantly increased muscle mass and contractility in the ‘running plus FST’ group, but running, with and without FST, showed no effect on motor unit degeneration. In contrast, running, with and without FST, demonstrated marked improvement of neuromuscular junction transmission stability.
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影响因子：
4.9
作者：
Hu X;Charles JP;Akay T;Hutchinson JR;Blemker SS
通讯作者：
Blemker SS
DOI：
10.1093/gerona/63.8.829
发表时间：
2008-08-01
影响因子：
5.1
作者：
Clark, Brian C.;Manini, Todd M.
通讯作者：
Manini, Todd M.
影响因子：
2.4
作者：
Elashry, Mohamed I.;Otto, Anthony;Patel, Ketan
通讯作者：
Patel, Ketan
影响因子：
8.8
作者：
Giorgetti, Elisa;Panesar, Moh;Nash, Mark
通讯作者：
Nash, Mark
影响因子：
2.5
作者：
Garvey, Sean M.;Russ, David W.;Edens, Neile K.
通讯作者：
Edens, Neile K.