Secondary primary malignancy risk among patients with esophageal cancer in Taiwan: a nationwide population-based study.
Secondary primary malignancy risk among patients with esophageal cancer in Taiwan: a nationwide population-based study.
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台湾食管癌患者的第二个原发性恶性风险：一项基于人群的研究。
DOI：
10.1371/journal.pone.0116384
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Liu CJ
中科院分区：
文献类型：
--
作者：
Chen SC;Teng CJ;Hu YW;Yeh CM;Hung MH;Hu LY;Ku FC;Tzeng CH;Chiou TJ;Chen TJ;Liu CJ
评估食管癌患者中异时性继发原发性恶性肿瘤（SPM）的风险和部位。招募了1997年至2011年间新诊断的食管癌患者。为了避免监测偏倚，排除了一年内发生的SPM。通过与普通人群的癌症发病率进行比较，计算这些患者异时性SPM的标准化发病率比（SIR）。SPM发生的危险因素，包括年龄、性别、合并症和癌症相关治疗，通过考克斯比例风险模型进行估计。在15年的研究期间，18，026名食管癌患者中发生了870例SPM，随访时间为27，056人年。所有癌症的SIR为3.53。随访期≥ 10年的SIR为3.56; 5-10年为3.14; 1-5年为3.06。头颈部、胃、肺、纵隔、肾、白血病的SIRs分别为15.83、3.30、2.10、2.24、2.72。多因素分析显示，年龄≥ 60岁（HR 0.74）、男性（HR 1.46）、肝硬化（HR 1.46）为独立影响因素。根据治疗，大手术（HR 1.24）增加了风险，但化疗几乎是显着的。食管癌患者发生异时性SPM的风险增加。SIR在> 10年的随访中仍然很高，因此可能需要密切监测这些食管癌患者中SPM的早期检测。
To evaluate the risk and sites of metachronous secondary primary malignancies (SPMs) among patients with esophageal cancer. Newly diagnosed esophageal cancer patients between 1997 and 2011 were recruited. To avoid surveillance bias, SPMs that developed within one year were excluded. Standardized incidence ratios (SIRs) of metachronous SPMs in these patients were calculated by comparing to the cancer incidence in the general population. Risk factors for SPM development, included age, sex, comorbidities and cancer-related treatments, were estimated by Cox proportional hazards models. During the 15-year study period, 870 SPMs developed among 18,026 esophageal cancer patients, with a follow-up of 27,056 person-years. The SIR for all cancers was 3.53. The SIR of follow-up period ≥ 10 years was 3.56; 5–10 years, 3.14; and 1–5 years, 3.06. The cancer SIRs of head and neck (15.83), stomach (3.30), lung and mediastinum (2.10), kidney (2.24) and leukemia (2.72), were significantly increased. Multivariate analysis showed that age ≥ 60 years (hazard ratio [HR] 0.74), being male (HR 1.46) and liver cirrhosis (HR 1.46) were independent factors. According to the treatments, major surgery (HR 1.24) increased the risk, but chemotherapy was nearly significant. Patients with esophageal cancer were at increased risk of developing metachronous SPMs. The SIR remained high in follow-up > 10 years, so that close monitoring may be needed for early detection of SPM among these esophageal cancer patients.
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影响因子：
5.2
作者：
Sugiura, T;Kato, H;Nakanishi, Y
通讯作者：
Nakanishi, Y
DOI：
10.1093/jnci/djk179
发表时间：
2007-05-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hashibe, Mia;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo
影响因子：
45.3
作者：
Matsubara, T;Yamada, K;Nakagawa, A
通讯作者：
Nakagawa, A
影响因子：
4.6
作者：
Poon, RTP;Law, SYK;Wong, J
通讯作者：
Wong, J
影响因子：
4.3
作者：
Anderson, Lesley A.;Watson, R. G. Peter;Murray, Liam J.
通讯作者：
Murray, Liam J.