Customized versus population approach for evaluation of fetal overgrowth.

Customized versus population approach for evaluation of fetal overgrowth.
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DOI:
10.1055/s-0032-1329188
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发表时间:
2013-08
影响因子:
2
通讯作者:
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland
中科院分区:
医学4区
文献类型:
--
作者:
Costantine MM;Mele L;Landon MB;Spong CY;Ramin SM;Casey B;Wapner RJ;Varner MW;Rouse DJ;Thorp JM Jr;Sciscione A;Catalano P;Caritis SN;Sorokin Y;Peaceman AM;Tolosa JE;Anderson GD;Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland

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To compare the ability of customized versus normalized population fetal growth norms in identifying neonates at risk for adverse perinatal outcomes (APOs) associated with fetal overgrowth and gestational diabetes (GDM). Secondary analysis of a multicenter treatment trial of mild GDM. The primary outcome was a composite of neonatal outcomes associated with fetal overgrowth and GDM. Birthweight percentiles were calculated using ethnicity- & gender-specific population norms and customized norms (Gardosi). 203 (9.8%) and 288 (13.8%) neonates were LGA by population (LGApop) and customized (LGAcust) norms, respectively. Both LGApop and LGAcust were associated with the primary outcome and neonatal hyperinsulinemia, while neither was associated with hypoglycemia or hyperbilirubinemia. The ability of customized and population birthweight percentiles for predicting APOs were poor (receiver operating characteristic area under the curve <0.6 for 6 out of 8 APOs). Neither customized nor normalized-population norms better identify neonates at risk of APOs related to fetal overgrowth and GDM.
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