Blood-nourishing and hard-softening capsule costs less in the management of osteoarthritic knee pain: a randomized controlled trial.
Blood-nourishing and hard-softening capsule costs less in the management of osteoarthritic knee pain: a randomized controlled trial.
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DOI：
10.1093/ecam/neh104
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发表时间：
2005-09
期刊：
影响因子：
--
通讯作者：
Lo SK
中科院分区：
文献类型：
--
作者：
Cao Y;Shi Y;Zheng Y;Shi M;Lo SK
养血硬软胶囊(BNHS)是一种用于对症治疗炎症和疼痛的中国传统配方。我们进行了这项随机对照试验，以比较BNHS与其他常用处方药的疗效。我们从两家教学医院招募了120名患者；每家医院的30名患者被随机分配到BNHS接受治疗。在一家医院，30名对照组服用另一种中药；而在另一家医院，对照组使用西药(软骨保护药/维亚曲利-S)。干预时间为4周。主要结果测量包括自我报告的疼痛水平，以及由西安大略省麦克马斯特大学骨关节炎(WOMAC)指数衡量的僵硬和功能能力的变化。采用混合模型进行统计分析。在服用BNHS胶囊的患者治疗4周后，观察到疾病特异性症状的显著改善。按WOMAC指数评定，BNHS组疼痛程度降低57%[95%可信区间=50，63]，僵硬程度降低63%(95%CI=55，71)，功能能力提高56%(95%CI=50，63)。在BNHS组和两个对照组之间的任何结果测量中都没有发现显著的差异。没有严重不良反应的报道。然而，这项研究缺乏安慰剂组；因此，我们得出结论，BNHS似乎与通常开出的药物一样有效，可以缓解膝骨性关节炎患者的疼痛和功能障碍，但成本比研究中的其他西药和草药低得多。
The blood-nourishing and hard-softening (BNHS) capsule is a traditional Chinese formula used in the symptomatic treatment of inflammation and pain. We conducted this randomized controlled trial to compare the efficacy of BNHS with other commonly prescribed drugs. We recruited 120 patients from two teaching hospitals; 30 patients in each hospital were randomly assigned to receive BNHS. In one hospital, the 30 controls were given another traditional Chinese drug; whereas a Western medicine (chondroprotection drug/Viartril-s) was used as the control in the other hospital. Intervention was carried out over a period of 4 weeks. Primary outcome measures included self-reported pain level, and changes in stiffness and functional ability as measured by the Western Ontario McMaster Universities Osteoarthritis (WOMAC) index. Mixed models were used for statistical analysis. Substantial improvements in disease-specific symptoms were observed, after 4 weeks of treatment, in patients taking BNHS capsules. As assessed by the WOMAC index, pain level of the BNHS group decreased by 57% [95% confidence interval (CI) = 50, 63], stiffness by 63% (95% CI = 55, 71) and functional ability increased by 56% (95% CI = 50, 63). No significant differences were found in any of the outcome measures between the BNHS group and either of the comparison groups. No severe adverse effects were reported. However, this study lacked a placebo group; therefore, we conclude that BNHS appears to be as effective as commonly prescribed medicines for the relief of pain and dysfunction in knee osteoarthritis patients, but costs a lot less than other Western and herbal drugs in the study.
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影响因子：
5.5
作者：
Berman, BM;Singh, BB;Hochberg, M
通讯作者：
Hochberg, M
DOI：
10.1001/archfami.9.10.1124
发表时间：
2000-11-01
期刊：
ARCHIVES OF FAMILY MEDICINE
影响因子：
--
作者：
Saag, K;van der Heijde, D;Daniels, B
通讯作者：
Daniels, B
DOI：
10.1002/art.1790070304
发表时间：
1994-09-01
期刊：
Arthritis care and research : the official journal of the Arthritis Health Professions Association
影响因子：
--
作者：
Takeda, W;Wessel, J
通讯作者：
Wessel, J
影响因子：
120.7
作者：
Geba, GP;Weaver, AL;Schnitzer, TJ
通讯作者：
Schnitzer, TJ
影响因子：
39.2
作者：
GRIFFIN, MR;PIPER, JM;RAY, WA
通讯作者：
RAY, WA