Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy.
Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy.
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赖氨酰氧化酶原在癌症和眼部病变中的作用和机制，重点是糖尿病视网膜病变。
DOI：
10.3390/ijms23095088
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发表时间：
2022-05-03
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
赖氨酰氧化酶是衍生自五种赖氨酰氧化酶旁系同源物（LOX）和赖氨酰氧化酶样1至赖氨酰氧化酶样4（LOXL 1-LOXL 4）的多功能蛋白质。所有这些都通过催化胶原蛋白和弹性蛋白中赖氨酸残基的氧化脱氨基作用参与结缔组织的生物合成和成熟，最终导致功能所需的交联的发展。此外，五种LOX基因在过表达时与纤维化和癌症有关，而来自LOX前体的前肽对肿瘤的抑制作用已被证明。类似地，在糖尿病视网膜病变中，LOX过表达、活性和LOX前肽升高已被记录。蛋白质的前体形式的蛋白水解加工开始引起人们的注意，因为所得的肽似乎表现出它们自己的生物活性。在这篇综述中，我们专注于LOX paralysts，什么是已知的关于其细胞外生物合成过程和仍然不完整的知识有关的活动和机制释放赖氨酰氧化酶前肽（LOX-PP）。此外，还包括LOX和LOX-PP在糖尿病视网膜病变中的作用的总结，以及LOX和密切相关的LOXL 1分别在青光眼和圆锥角膜中的作用的简要提及。
Lysyl oxidases are multifunctional proteins derived from five lysyl oxidase paralogues (LOX) and lysyl oxidase-like 1 through lysyl oxidase-like 4 (LOXL1–LOXL4). All participate in the biosynthesis of and maturation of connective tissues by catalyzing the oxidative deamination of lysine residues in collagens and elastin, which ultimately results in the development of cross-links required to function. In addition, the five LOX genes have been linked to fibrosis and cancer when overexpressed, while tumor suppression by the propeptide derived from pro-LOX has been documented. Similarly, in diabetic retinopathy, LOX overexpression, activity, and elevated LOX propeptide have been documented. The proteolytic processing of pro-forms of the respective proteins is beginning to draw attention as the resultant peptides appear to exhibit their own biological activities. In this review we focus on the LOX paralogue, and what is known regarding its extracellular biosynthetic processing and the still incomplete knowledge regarding the activities and mechanisms of the released lysyl oxidase propeptide (LOX-PP). In addition, a summary of the roles of both LOX and LOX-PP in diabetic retinopathy, and brief mentions of the roles for LOX and closely related LOXL1 in glaucoma, and keratoconus, respectively, are included.
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影响因子：
3.7
作者：
Bais MV;Nugent MA;Stephens DN;Sume SS;Kirsch KH;Sonenshein GE;Trackman PC
通讯作者：
Trackman PC
关键缺氧调节的下游分子和前列腺癌的表型相关性的遗传多态性。
影响因子：
2
作者：
Fraga A;Ribeiro R;Coelho A;Vizcaíno JR;Coutinho H;Lopes JM;Príncipe P;Lobato C;Lopes C;Medeiros R
通讯作者：
Medeiros R
DOI：
10.1177/039463200501800311
发表时间：
2005-07-01
影响因子：
3.5
作者：
Carinci, F;Lo Muzio, L;Pezzetti, F
通讯作者：
Pezzetti, F
影响因子：
4.8
作者：
Borel, A;Eichenberger, D;Font, B
通讯作者：
Font, B
影响因子：
1.2
作者：
de Juan-Marcos, Lourdes;Escudero-Dominguez, Francisco A.;Gonzalez-Sarmiento, Rogelio
通讯作者：
Gonzalez-Sarmiento, Rogelio