Mega-scale movie-fields in the mouse visuo-hippocampal network.
Mega-scale movie-fields in the mouse visuo-hippocampal network.
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DOI：
10.7554/elife.85069
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发表时间：
2023-11-01
期刊：
影响因子：
7.7
通讯作者：
Mehta M
中科院分区：
文献类型：
--
作者：
Purandare C;Mehta M
自然的视觉体验包括一系列连续的相关图像，而主体是不动的。皮质-海马回路如何处理视觉事件？海马体对情景记忆至关重要，但大多数啮齿动物单一单元研究需要空间探索或主动参与。因此，我们研究了头部固定小鼠对无声电影（艾伦脑天文台）的神经反应，没有任何任务或运动要求，或奖励。令人惊讶的是，三分之一（33%，3379/10263）的海马齿状回、CA 3、CA 1和下托神经元显示出电影选择性，在特定的电影子段（称为电影场）中放电升高，与绝大多数丘脑-皮质（LGN、V1、AM-PM）神经元（97%，6554/6785）相似。在不动或自发奔跑的小鼠中，电影调谐保持不变。视觉神经元每个细胞有>5个电影场，而海马只有~2个。所有大脑区域的电影场持续时间跨越了前所未有的1000倍范围：从0.02秒到20秒，称为大规模编码。然而，一个细胞的所有电影场的总持续时间在神经元和大脑区域之间是相当的。海马的反应，因此表现出更大的连续序列编码比视觉区，证明了更少和更广泛的电影领域比视觉区。一致地，重复呈现电影图像在一个固定的，但混乱的序列几乎取消海马，但不是视觉皮层的选择性。连续的偏好，乱序相比，在海马比视觉区大8倍，进一步支持情节序列编码。因此，电影可以提供一种统一的方式来探索情节信息处理和记忆的神经机制，即使是在不动的受试者中，跨大脑区域和物种。
Natural visual experience involves a continuous series of related images while the subject is immobile. How does the cortico-hippocampal circuit process a visual episode? The hippocampus is crucial for episodic memory, but most rodent single unit studies require spatial exploration or active engagement. Hence, we investigated neural responses to a silent movie (Allen Brain Observatory) in head-fixed mice without any task or locomotion demands, or rewards. Surprisingly, a third (33%, 3379/10263) of hippocampal –dentate gyrus, CA3, CA1 and subiculum– neurons showed movie-selectivity, with elevated firing in specific movie sub-segments, termed movie-fields, similar to the vast majority of thalamo-cortical (LGN, V1, AM-PM) neurons (97%, 6554/6785). Movie-tuning remained intact in immobile or spontaneously running mice. Visual neurons had >5 movie-fields per cell, but only ~2 in hippocampus. The movie-field durations in all brain regions spanned an unprecedented 1000-fold range: from 0.02s to 20s, termed mega-scale coding. Yet, the total duration of all the movie-fields of a cell was comparable across neurons and brain regions. The hippocampal responses thus showed greater continuous-sequence encoding than visual areas, as evidenced by fewer and broader movie-fields than in visual areas. Consistently, repeated presentation of the movie images in a fixed, but scrambled sequence virtually abolished hippocampal but not visual-cortical selectivity. The preference for continuous, compared to scrambled sequence was eight-fold greater in hippocampal than visual areas, further supporting episodic-sequence encoding. Movies could thus provide a unified way to probe neural mechanisms of episodic information processing and memory, even in immobile subjects, across brain regions, and species.
影响因子：
3.5
作者：
Kampa BM;Roth MM;Göbel W;Helmchen F
通讯作者：
Helmchen F