Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex.
Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex.
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DOI：
10.3389/fncir.2011.00018
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发表时间：
2011
影响因子：
3.5
通讯作者：
Helmchen F
中科院分区：
文献类型：
--
作者：
Kampa BM;Roth MM;Göbel W;Helmchen F
视觉场景是如何在视觉皮层的局部神经网络中编码的？在啮齿类动物中，视觉皮层缺乏柱状组织，因此视觉空间中一个点的不同特征的处理可以由邻近神经元的群体局部执行。为了研究复杂的视觉场景是如何被小鼠视觉皮层中的局部微电路所代表的，我们使用3D双光子钙成像测量了第2/3层神经元群体的视觉诱发反应。自然和人工的电影场景（10秒持续时间）诱发分布和稀疏组织的反应，在70-150个神经元的局部群体内的采样体积。大约50%的神经元在视觉场景呈现过程中表现出钙瞬变，其中大约一半表现出可靠的时间激活模式。大多数可靠的反应神经元主要被所应用的四个视觉场景之一激活。因此，单神经元在解码视觉场景时表现不佳。相比之下，当考虑群体响应时，达到高水平的解码性能（>80%），需要约80个随机挑选的细胞或20个可靠的响应者。此外，可靠的反应神经元往往有邻居共享相同的刺激偏好。由于这种局部冗余，从空间分布而不是局部聚集的神经元读出活动对于有效的场景解码是有益的。我们的研究结果表明，在2/3层的视觉皮层，视觉环境是动态表示在不同的功能子网络的激活人口代码。
How are visual scenes encoded in local neural networks of visual cortex? In rodents, visual cortex lacks a columnar organization so that processing of diverse features from a spot in visual space could be performed locally by populations of neighboring neurons. To examine how complex visual scenes are represented by local microcircuits in mouse visual cortex we measured visually evoked responses of layer 2/3 neuronal populations using 3D two-photon calcium imaging. Both natural and artificial movie scenes (10 seconds duration) evoked distributed and sparsely organized responses in local populations of 70–150 neurons within the sampled volumes. About 50% of neurons showed calcium transients during visual scene presentation, of which about half displayed reliable temporal activation patterns. The majority of the reliably responding neurons were activated primarily by one of the four visual scenes applied. Consequently, single-neurons performed poorly in decoding, which visual scene had been presented. In contrast, high levels of decoding performance (>80%) were reached when considering population responses, requiring about 80 randomly picked cells or 20 reliable responders. Furthermore, reliable responding neurons tended to have neighbors sharing the same stimulus preference. Because of this local redundancy, it was beneficial for efficient scene decoding to read out activity from spatially distributed rather than locally clustered neurons. Our results suggest a population code in layer 2/3 of visual cortex, where the visual environment is dynamically represented in the activation of distinct functional sub-networks.
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影响因子：
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作者：
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作者：
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