alpha-Ketoisocaproate is superior to leucine in sparing glucose utilization in humans.
alpha-Ketoisocaproate is superior to leucine in sparing glucose utilization in humans.
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α-酮异己酸在减少人类葡萄糖利用方面优于亮氨酸。
DOI：
10.1152/ajpendo.1986.251.6.e648
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Abumrad,N
中科院分区：
文献类型：
--
作者：
Buckspan,R;Hoxworth,B;Cersosimo,E;Devlin,J;Horton,E;Abumrad,N
本研究旨在检测亮氨酸及其酮酸α-酮异己酸酯（KIC）在体内的葡萄糖节约作用。对两组禁食过夜的正常志愿者进行了研究。第一组中，8 名受试者接受亮氨酸静脉输注，6 名受试者接受 KIC（2.3 mumol X kg-1 X min-1）3 小时；另一次，所有受试者都接受了生理盐水并充当自己的对照。在第二组中，11 名受试者接受 1 mU X kg-1 X min-1 输注 3 小时，同时输注可变葡萄糖以维持血糖正常。另一次，五名受试者接受了额外的亮氨酸输注，六名受试者分别接受了 KIC，剂量为 2.3 mumol X kg-1 X min-1，持续 3 小时。以维持血糖正常所需的外源葡萄糖量（M，mg X kg-1 X min-1）作为全身葡萄糖利用率的指标。测定两组的前臂亮氨酸、KIC、葡萄糖和乳酸交换。单独输注亮氨酸和 KIC 均可降低葡萄糖摄取（分别为 42% 和 40%），并增加乳酸释放（分别为 37% 和 116%）。高胰岛素血症（基础值的 6 倍）和血糖正常导致人类前臂的葡萄糖摄取增加五倍。维持血糖正常所需的外源葡萄糖量平均为 7.4 +/- 0.5 mg X kg-1 X min-1。亮氨酸和胰岛素输注的组合不会改变刺激的前臂葡萄糖摄取，也不会改变 M（7.25 +/- 0.6 mg X kg-1 X min-1，P = NS）。（摘要截断为 250 字）
The present study was designed to examine the glucose-sparing effect of leucine and its keto acid alpha-ketoisocaproate (KIC) in vivo. Two groups of overnight-fasted normal volunteers were studied. In the first group, eight subjects received an intravenous infusion of leucine and six subjects received KIC (2.3 mumol X kg-1 X min-1) for 3 h; on another occasion, all subjects received saline and acted as their own controls. In the second group, 11 subjects received an infusion of 1 mU X kg-1 X min-1 for 3 h with a variable glucose infusion to maintain euglycemia. On another occasion, five subjects received an additional infusion of leucine and six subjects received KIC each at 2.3 mumol X kg-1 X min-1 for 3 h. The amount of exogenous glucose required to maintain euglycemia (M, mg X kg-1 X min-1) was used as an index of total body glucose utilization. Forearm exchange of leucine, KIC, glucose, and lactate was determined in both groups. Both leucine and KIC infusions alone decreased glucose uptake (42 and 40%) and increased lactate release (37 and 116%, respectively). Hyperinsulinemia (6-fold basal) and euglycemia resulted in a fivefold increase in glucose uptake across the human forearm. The amount of exogenous glucose required to maintain euglycemia averaged 7.4 +/- 0.5 mg X kg-1 X min-1. The combination of leucine and insulin infusions did not alter the stimulated forearm glucose uptake nor did it change M (7.25 +/- 0.6 mg X kg-1 X min-1, P = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
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支链氨基酸和酮酸的治疗方面。
影响因子：
6
作者：
M. Walser
通讯作者：
M. Walser
大鼠离体心脏和隔膜对支链氨基酸的氧化。
影响因子：
4.8
作者：
M. Buse;J. F. Biggers;K. Friderici;J. Buse
通讯作者：
J. Buse
进食和禁食大鼠的隔膜对氨基酸的氧化。
影响因子：
--
作者：
A. Goldberg;R. Odessey
通讯作者：
R. Odessey
胰岛素在清醒狗亮氨酸动力学调节中的作用。
DOI：
10.1172/jci110690
发表时间：
1982
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Abumrad,NN;Jefferson,LS;Rannels,SR;Williams,PE;Cherrington,AD;Lacy,WW
通讯作者：
Lacy,WW
影响因子：
9.8
作者：
ABUMRAD, NN;RABIN, D;LACY, WW
通讯作者：
LACY, WW