Prognostic role of microRNA-221 in various human malignant neoplasms: a meta-analysis of 20 related studies.
Prognostic role of microRNA-221 in various human malignant neoplasms: a meta-analysis of 20 related studies.
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MicroRNA-221在各种人类恶性肿瘤中的预后作用：20项相关研究的荟萃分析。
DOI：
10.1371/journal.pone.0087606
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yin CJ
中科院分区：
文献类型：
--
作者：
Yang J;Zhang JY;Chen J;Xu Y;Song NH;Yin CJ
MicroRNA-221（miR-221）在癌症预后中发挥重要作用。为了评估miR-221的预测价值，我们收集了20项符合条件的研究的证据进行荟萃分析。通过检索PubMed、Embase和Web of Science确定所有相关研究，并进行进一步的质量评价。计算总生存期（OS）和无复发生存期（RFS）的总体和分层分析的合并风险比（HR）和95%置信区间（CI），以研究miR-221高表达与癌症预后之间的相关性。我们发现，miR-221高表达可预测恶性肿瘤的OS较差（合并HR = 1.55，P = 0.017），但与RFS无显著相关性（合并HR = 1.02，P = 0.942）。 进一步在分层分析中，高miR-221表达与亚洲人（合并HR = 2.04，P = 0.010）或血清/血浆亚组（合并HR = 2.28，P<0.001）的OS差显著相关，甚至在肝细胞癌（HCC）亚组中显示出显著差的OS（合并HR= 1.80，P<0.001）和RFS（合并HR = 2.43，P =0.010），但与前列腺癌亚组中的有利RFS相关（合并HR= 0.51，P = 0.004）。 我们的研究结果表明，miR-221更适合于预测亚洲人的癌症预后，是一种有前途的HCC预后生物标志物。血清或血浆样本中miR-221的检测可能使其成为未来监测患者预后和评估治疗效果的有效方法。
MicroRNA-221 (miR-221) has been shown to play an important role in cancer prognosis. In order to evaluate the predictive value of miR-221, we compiled the evidence from 20 eligible studies to perform a meta-analysis. All of relevant studies were identified by searching PubMed, Embase, and Web of Science, and were assessed by further quality evaluation. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) of total and stratified analyses, for overall survival (OS) and recurrence-free survival (RFS), were calculated to investigate the association between high miR-221 expression and cancer prognosis. We found that high miR-221 expression can predict a poor OS in malignant tumors (pooled HR = 1.55, P = 0.017) but has no significant association with RFS (pooled HR = 1.02, P = 0.942). Further in stratified analyses, high miR-221 expression was significantly associated with a poor OS in Asians (pooled HR = 2.04, P = 0.010) or serum/ plasma subgroup (pooled HR = 2.28, P<0.001), and even showed significantly poor OS (pooled HR = 1.80, P<0.001) and RFS (pooled HR = 2.43, P = 0.010) in hepatocellular carcinoma (HCC) subgroup, but was correlated to a favorable RFS in prostate cancer subgroup (pooled HR = 0.51, P = 0.004). Our findings demonstrate that miR-221 is more suitable to predict cancer prognosis in Asians, and it is a promising prognostic biomarker for HCC. The detection of miR-221 in serum or plasma samples may make it become an effective method for monitoring patients' prognosis and assessing therapeutic efficacy in the future.
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