Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.
Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.
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通过分子MRI淬灭进行治疗和治疗监测的环境反应性纳米机。
DOI：
10.1038/ncomms4384
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发表时间：
2014-03-04
影响因子：
16.6
通讯作者：
Grimm, Jan
中科院分区：
文献类型：
--
作者：
Kaittanis, Charalambos;Shaffer, Travis M.;Ogirala, Anuja;Santra, Santimukul;Perez, J. Manuel;Chiosis, Gabriela;Li, Yueming;Josephson, Lee;Grimm, Jan
将治疗剂有效递送至疾病部位显著有助于药物功效、毒性和清除。在这里，我们证明了临床批准的氧化铁纳米颗粒（Ferumoxytol）可用于携带一种或多种药物。这些所谓的“纳米载体”通过弱静电相互作用将其货物保留在其聚合物涂层内，并在微酸性条件下（pH 6.8及以下）释放。药物的负载增加了纳米载体的横向T2和纵向T1 NMR质子弛豫时间，这与所携带的货物的量成比例。在体外和体内，使用翻译纳米载体的化疗比游离药物更有效，而无需对药物或载体纳米颗粒进行任何化学修饰。可以通过台式磁弛豫仪、普通NMR仪器或MRI扫描仪评估体外和体内货物掺入和有效载荷水平。
The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called ‘nanophores’ retain their cargo within their polymeric coating through weak electrostatic interactions and release it in slightly acidic conditions (pH 6.8 and below). The loading of drugs increases the nanophores’ transverse T2 and longitudinal T1 NMR proton relaxation times, which is proportional to amount of carried cargo. Chemotherapy with translational nanophores is more effective than the free drug in vitro and in vivo, without subjecting the drugs or the carrier nanoparticle to any chemical modification. Evaluation of cargo incorporation and payload levels in vitro and in vivo can be assessed via benchtop magnetic relaxometers, common NMR instruments or MRI scanners.
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影响因子：
8.6
作者：
Nath, Sudip;Kaittanis, Charalambos;Ramachandran, Vasanth;Dalal, Naresh S.;Perez, J. Manuel
通讯作者：
Perez, J. Manuel
影响因子：
7.4
作者：
Koh, Isaac;Hong, Rui;Weissleder, Ralph;Josephson, Lee
通讯作者：
Josephson, Lee
影响因子：
50.5
作者：
O'Brien, MER;Wigler, N;Tendler, C
通讯作者：
Tendler, C
影响因子：
4.9
作者：
Kularatne, Sumith A.;Wang, Kevin;Low, Philip S.
通讯作者：
Low, Philip S.
影响因子：
11.2
作者：
Grimm, J;Perez, JM;Weissleder, R
通讯作者：
Weissleder, R