Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis.
Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis.
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大鼠肌肉中的支链氨基酸代谢：酸中毒的异常调节。
DOI：
10.1152/ajpendo.1987.252.6.e712
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Mitch,WE
中科院分区：
文献类型：
--
作者：
May,RC;Hara,Y;Kelly,RA;Block,KP;Buse,MG;Mitch,WE
Branched-chain amino acid (BCAA) metabolism is frequently abnormal in pathological conditions accompanied by chronic metabolic acidosis. To study how metabolic acidosis affects BCAA metabolism in muscle, rats were gavage fed a 14% protein diet with or without 4 mmol NH4Cl X 100 g body wt-1 X day-1. Epitrochlearis muscles were incubated with L-[1-14C]-valine and L-[1-14C]leucine, and rates of decarboxylation, net transamination, and incorporation into muscle protein were measured. Plasma and muscle BCAA levels were lower (P less than 0.05) in acidotic rats. Rates of valine and leucine decarboxylation and net transamination were higher (P less than 0.05) in muscles from acidotic rats; these differences were associated with a 79% increase in the total activity of branched-chain alpha-keto acid dehydrogenase and a 146% increase in the activated form of the enzyme. We conclude that acidosis affects the regulation of BCAA metabolism by enhancing flux through the transaminase and by directly stimulating oxidative catabolism through activation of branched-chain alpha-keto acid dehydrogenase.
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人表皮细胞在培养物中生长后失去 HLA-DR 表达。
DOI：
10.1111/1523-1747.ep12261671
发表时间：
1984
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
J. Hefton;J. Amberson;D. G. Biozes;M. Weksler
通讯作者：
M. Weksler
影响因子：
13.5
作者：
Z. Darżynkiewicz
通讯作者：
Z. Darżynkiewicz
小鼠表皮中细胞快速和缓慢进展至 G2 期的证据：通过不同方法测量的阶段持续时间之间的比较
DOI：
--
发表时间：
1981
期刊：
Cell and tissue kinetics
影响因子：
--
作者：
O. Clausen;E. Thorud;E. Aarnæs
通讯作者：
E. Aarnæs
二羟基蒽醌对多种培养哺乳动物细胞的细胞周期进展和存活的作用。
影响因子：
11.2
作者：
Traganos,F;Evenson,DP;Staiano-Coico,L;Darzynkiewicz,Z;Melamed,MR
通讯作者：
Melamed,MR
影响因子：
3.7
作者：
S. Melbye;M. Karasek
通讯作者：
S. Melbye;M. Karasek