Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study.
Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study.
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Framingham 后代研究中细胞间粘附分子 1 的遗传力和相关性。
DOI：
10.1016/j.jacc.2004.03.048
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发表时间：
2004
影响因子：
24
通讯作者：
Benjamin,EmeliaJ
中科院分区：
文献类型：
--
作者：
KeaneyJr,JohnF;Massaro,JosephM;Larson,MartinG;Vasan,RamachandranS;Wilson,PeterWF;Lipinska,Izabella;Corey,Diane;Sutherland,Patrice;Vita,JosephA;Benjamin,EmeliaJ
ObjectivesWe试图确定与炎症相关的临床因素和遗传性，这些因素通过在以社区为基础的队列中测定循环中可溶性细胞间粘附分子-1（sICAM-1）的水平来衡量。然而，在一些研究中，在对传统的心血管疾病（CVD）危险因素进行多变量校正后，这种预测值丢失。我们解决了sICAM-1的遗传性及其与心血管疾病的危险因素在以社区为基础的coherent.MethodsWe检查了3,295例受试者心脏研究和测量sICAM-1水平。然后，我们使用线性和逐步多变量回归，以确定预测因子或sICAM-1 levels.ResultsIn年龄和性别调整的回归模型，增加sICAM-1水平呈正相关的年龄，总/高密度脂蛋白胆固醇，收缩压，体重指数（BMI），血糖，糖尿病，吸烟，和流行的心血管疾病。在逐步多变量回归模型中，sICAM-1水平与年龄、女性、总/高密度脂蛋白胆固醇比、BMI、血糖、吸烟和CVD患病率相关。sICAM-1的剩余遗传度为24%。结论sICAM-1水平与全身炎症反应有关，除了普遍存在的CVD外，已确定的CVD危险因素和非传统因素如BMI也与全身炎症反应有关。sICAM-1也有显著的遗传性，这表明全身性炎症的遗传成分。
ObjectivesWe sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort.BackgroundSeveral prospective studies indicate that circulating sICAM-1 is predictive of future cardiovascular events. However, in some studies this predictive value is lost after multivariable adjustment for traditional cardiovascular disease (CVD) risk factors. We addressed the heritability of sICAM-1 and its relation to CVD risk factors in a community-based cohort.MethodsWe examined 3,295 subjects from the Framingham Heart Study and measured sICAM-1 levels. We then used linear and stepwise multivariable regression to determine predictors or sICAM-1 levels.ResultsIn age- and gender-adjusted regression models, increased sICAM-1 levels were positively associated with age, total/high-density lipoprotein cholesterol, systolic blood pressure, body mass index (BMI), blood glucose, diabetes, smoking, and prevalent CVD. In stepwise multivariable regression models, sICAM-1 levels remained associated with age, female gender, total/high-density lipoprotein cholesterol ratio, BMI, blood glucose, smoking, and prevalent CVD. The residual heritability of sICAM-1 was 24%.ConclusionsIn addition to prevalent CVD, established CVD risk factors and non-traditional ones such as BMI were associated with systemic inflammation as determined by sICAM-1 levels. There also is significant heritability of sICAM-1, which suggests a genetic component to systemic inflammation.
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作者：
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通讯作者：
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作者：
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