Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis.
Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis.
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IL-10 在小鼠对粗球孢子菌遗传易感性中的重要性。
DOI：
10.1128/iai.66.9.4397-4402.1998
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发表时间：
1998
影响因子：
3.1
通讯作者：
Kirkland,TN
中科院分区：
文献类型：
--
作者：
Fierer,J;Walls,L;Eckmann,L;Yamamoto,T;Kirkland,TN
Inbred strains of mice vary in their susceptibility toCoccidioides immitis. We infected resistant DBA/2 (D2) mice and three susceptible strains of mice (C57BL/6 [B6], BALB/c, and CAST/Ei) by intraperitoneal injection of arthroconidia and determined the severity of infection based on colony counts of fungus in the spleens and lungs 14 days after infection. We used quantitative reverse transcription-PCR to measure the amounts of cytokines made in the spleens and lungs of infected mice. Susceptible mice made 1,000-fold more interleukin-10 (IL-10) than resistant D2 mice and about 10-fold more IL-4. In contrast, D2 mice had more IL-12 p40 in their lungs than did B6 mice. Resistant and susceptible mice made equivalent amounts of gamma interferon, IL-6, and IL-2. In order to determine whether IL-10 adversely affected the response toC. immitis, we infected IL-10-deficient mice, and they were found to be as resistant as D2 mice. This result indicates that IL-10 plays a crucial role in determining susceptibility toC. immitisin inbred mice. Because IL-4 mRNA levels were higher in most strains of susceptible mice, we also infected IL-4-deficient B6 mice. They were more resistant than B6 controls but not as resistant as IL-10-deficient mice. Thus, both IL-10 and IL-4 adversely affect the ability of C57BL mice to resist infection withC. immitis, but IL-10 has a larger effect and is the cytokine that is consistently associated with susceptibility in all strains of inbred mice.
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影响因子：
4.4
作者：
P. Sieling;J. Abrams;M. Yamamura;Padmini Salgame;Barry R. Bloom;T. Rea;R. Modlin
通讯作者：
P. Sieling;J. Abrams;M. Yamamura;Padmini Salgame;Barry R. Bloom;T. Rea;R. Modlin
影响因子：
11.4
作者：
Kubo, M;Ransom, J;Nakayama, T
通讯作者：
Nakayama, T
IL-10 对实验性小鼠血吸虫病 T 辅助细胞反应的调节。
DOI：
--
发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
FloresVillanueva,PO;Reiser,H;Stadecker,MJ
通讯作者：
Stadecker,MJ
人球孢子菌病中外周血单核细胞产生细胞因子。
DOI：
10.1093/infdis/174.2.440
发表时间：
1996
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Corry,DB;Ampel,NM;Christian,L;Locksley,RM;Galgiani,JN
通讯作者：
Galgiani,JN
宿主-寄生虫模型中 CD4 T 细胞功能的启动和调节（第 2 部分，共 2 部分）
DOI：
--
发表时间：
1996
期刊：
影响因子：
--
作者：
Dragana Jankovic;A. Sher
通讯作者：
A. Sher