Clinicopathological characteristics of triple-negative invasive mammary carcinomas in African-American versus Caucasian women.
Clinicopathological characteristics of triple-negative invasive mammary carcinomas in African-American versus Caucasian women.
复制标题
非裔美国女性与白人女性三阴性浸润性乳腺癌的临床病理学特征。
DOI：
--
复制
发表时间：
2010
影响因子：
0.8
通讯作者：
P. Thomas
中科院分区：
文献类型：
--
作者：
O. Tawfik;K. Davis;B. Kimler;Marilyn K. Davis;S. Hull;F. Fan;Q. Khan;A. O'Dea;P. Thomas
非裔美国人（AA）女性更有可能患有晚期，侵袭性，快速生长和对乳腺癌反应性较低的乳腺肿瘤。据报道，一种侵袭性癌症亚型，称为“三阴性”（TN），即Her-2和雌激素和孕激素受体（ER和PR）阴性，在AA女性中更常见。我们研究了AA和白人女性TN肿瘤的临床、组织病理学和预后特征。评估肿瘤大小、分级、组织学类型、淋巴管浸润（LVI）、淋巴结状态、患者生存率、倍性状态以及ER、PR、p53、表皮生长因子受体（EGFR）、MIB-1、Bcl-2、Her-2、p27和p21的表达。TN肿瘤（75%）是高级别、大的非整倍体肿瘤，发生在年轻女性中，更可能具有高的LVI率、MIB-1评分升高和淋巴结转移。TN肿瘤患者的总体生存率较差。AA与高加索女性的总体或无病生存率无差异（p = 0.46）。LVI是AA患者总生存率的重要预测因子，但在白人女性中则不然。AA和白人TN肿瘤患者在组织病理学特征、生物标志物表达和生存率方面存在微小差异。AA患者中LVI的缺失预示着极好的生存概率。
African-American (AA) women are more likely to have late stage, aggressive, rapidly growing, and less hormone-responsive breast tumors. An aggressive subtype of cancer, known as "Triple-Negative" (TN), that is negative for Her-2 and for estrogen and progesterone receptors (ER and PR), is reported to be more common in AA women. We examined the clinical, histopathologic, and prognostic features of TN tumors in AA and Caucasian women. Tumor size, grade, histologic type, lymphovascular invasion (LVI), lymph node status, patient survival, ploidy status, and expression of ER, PR, p53, epidermal growth factor receptor (EGFR), MIB-1, Bcl-2, Her-2, p27, and p21 were evaluated. The TN tumors (75%) were high grade, large, aneuploid tumors that occurred in younger women and were more likely to have a high rate of LVI, elevated MIB-1 score, and nodal metastases. Patients with TN tumors showed poorer overall survival. There was no difference in overall or disease-free survival (p = 0.46) in the AA versus Caucasian women. LVI was a significant predictor of overall survival in AA but not in Caucasian women. There were minor differences in histopathologic features, biomarker expressions, and survival in AA and Caucasian women with TN tumors. The absence of LVI in AA patients predicted an excellent probability of survival.
转移性乳腺癌临床结果的种族差异：CALGB 9342 和 9840 - 癌症和白血病 B 组的汇总分析。
DOI：
10.1200/jco.2007.13.9782
发表时间：
2008
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Polite,BlaseN;Cirrincione,Constance;Fleming,GiniF;Berry,DonaldA;Seidman,Andrew;Muss,Hyman;Norton,Larry;Shapiro,Charles;Bakri,Kamal;Marcom,Kelly;Lake,Diana;Schwartz,JoelH;Hudis,Clifford;Winer,EricP
通讯作者：
Winer,EricP
影响因子：
120.7
作者：
Carey, Lisa A.;Perou, Charles M.;Millikan, Robert C.
通讯作者：
Millikan, Robert C.