Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear.
Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear.
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DOI：
10.1007/s12264-023-01130-w
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发表时间：
2024-01
影响因子：
5.6
通讯作者：
Chai, Renjie
中科院分区：
文献类型：
--
作者：
Qi, Jieyu;Huang, Wenjuan;Lu, Yicheng;Yang, Xuehan;Zhou, Yinyi;Chen, Tian;Wang, Xiaohan;Yu, Yafeng;Sun, Jia-Qiang;Chai, Renjie
听力损失已变得越来越普遍，并造成相当大的残疾，从而严重负担全球经济。毛细胞的不可逆损失是感音神经性听力损失的主要原因，目前，唯一相对有效的临床治疗仅限于数字听力设备，如人工耳蜗和助听器，但这些对患者的益处有限。因此，迫切需要了解损伤修复的机制，以开发新的神经保护策略。如何促进功能性毛细胞的再生是目前听力研究领域的一个关键科学问题。多种信号通路和转录因子触发毛细胞祖细胞的激活，确保新生毛细胞的成熟，在本文中，我们首先回顾毛细胞繁殖的主要机制。然后，我们进一步讨论了涉及多个信号通路的共同调节，以诱导有效的功能性毛细胞再生后变性的治疗策略，我们总结了目前在毛细胞再生的成就。最后，我们讨论了潜在的未来的方法，如小分子药物和基因治疗，这可能会应用于再生功能的毛细胞在临床上。
Hearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of hair cells is a main cause of sensorineural hearing loss, and currently, the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids, but these are of limited benefit in patients. It is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective strategies. At present, how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing research. Multiple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells, and in this article, we first review the principal mechanisms underlying hair cell reproduction. We then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration, and we summarize current achievements in hair cell regeneration. Lastly, we discuss potential future approaches, such as small molecule drugs and gene therapy, which might be applied for regenerating functional hair cells in the clinic.
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影响因子：
3
作者：
Zarei S;Zarei K;Fritzsch B;Elliott KL
通讯作者：
Elliott KL
影响因子：
64.8
作者：
Chen, Wei;Jongkamonwiwat, Nopporn;Abbas, Leila;Eshtan, Sarah Jacob;Johnson, Stuart L.;Kuhn, Stephanie;Milo, Marta;Thurlow, Johanna K.;Andrews, Peter W.;Marcotti, Walter;Moore, Harry D.;Rivolta, Marcelo N.
通讯作者：
Rivolta, Marcelo N.
影响因子：
11.8
作者：
Ahmed, Mohi;Wong, Elaine Y. M.;Sun, Jianbo;Xu, Jinshu;Wang, Feng;Xu, Pin-Xian
通讯作者：
Xu, Pin-Xian
影响因子：
3.7
作者：
Burns JC;Yoo JJ;Atala A;Jackson JD
通讯作者：
Jackson JD
影响因子：
4.6
作者：
Barker, Nick;Tan, Shawna;Clevers, Hans
通讯作者：
Clevers, Hans