MicroRNA-31 is required for astrocyte specification.
MicroRNA-31 is required for astrocyte specification.
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作者：
Meares GP;Rajbhandari R;Gerigk M;Tien CL;Chang C;Fehling SC;Rowse A;Mulhern KC;Nair S;Gray GK;Berbari NF;Bredel M;Benveniste EN;Nozell SE
Previously, we determined microRNA-31 (miR-31) is a non-coding tumor suppressive gene frequently deleted in glioblastoma (GBM); miR-31 suppresses tumor growth, in part, by limiting the activity of NF-κB. Herein, we expand our previous studies by characterizing the role of miR-31 during neural precursor cell (NPC) to astrocyte differentiation. We demonstrate that miR-31 expression and activity is suppressed in NPCs by stem cell factors such as Lin28, c-Myc, SOX2 and Oct4. However, during astrocytogenesis, miR-31 is induced by STAT3 and SMAD1/5/8, which mediate astrocyte differentiation. We determined miR-31 is required for terminal astrocyte differentiation, and that the loss of miR-31 impairs this process and/or prevents astrocyte maturation. We demonstrate that miR-31 promotes astrocyte development, in part, by reducing the levels of Lin28, a stem cell factor implicated in NPC renewal. These data suggest that miR-31 deletions may disrupt astrocyte development and/or homeostasis.
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影响因子：
6.2
作者：
Lippman, Jocelyn J.;Lordkipanidze, Tamar;Buell, Margaret E.;Yoon, Sung Ok;Dunaevsky, Anna
通讯作者：
Dunaevsky, Anna
影响因子：
25
作者：
Glasgow, Stacey M.;Zhu, Wenyi;Stolt, C. Claus;Huang, Teng-Wei;Chen, Fuyi;LoTurco, Joseph J.;Neul, Jeffrey L.;Wegner, Michael;Mohila, Carrie;Deneen, Benjamin
通讯作者：
Deneen, Benjamin
影响因子：
5.3
作者：
Fukuda, Shinji;Abematsu, Masahiko;Taga, Tetsuya
通讯作者：
Taga, Tetsuya
影响因子：
7.3
作者：
Bolego, C;Ceruti, S;Abbracchio, MP
通讯作者：
Abbracchio, MP
DOI：
10.1073/pnas.1403286111
发表时间：
2014-07-15
影响因子：
11.1
作者：
Koemeter-Cox, Andrew I.;Sherwood, Thomas W.;Mykytyn, Kirk
通讯作者：
Mykytyn, Kirk