Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens

Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens
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三个外显子的不同使用产生至少五种编码人类白细胞共同抗原的不同mRNA

DOI:
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发表时间:
1987
影响因子:
15.3
通讯作者:
H. Saito
H. Saito
中科院分区:
医学1区
文献类型:
--
作者:
M. Streuli;L. Hall;Y. Saga;S. Schlossman;H. Saito

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Leukocyte common antigens (LCAs, also known as T200 and CD 45) are integral membrane proteins expressed exclusively on hematopoietic cells. These molecules exhibit varying molecular masses and epitopes when expressed in different cell types. To determine the genetic bases for the generation of this diversity, three classes of human LCA cDNA clones that are different near their 5' ends have been isolated. These differences arose as a result of differential usage of three exons as determined from an analysis of a genomic DNA clone. Furthermore, Northern blot analysis with LCA exon-specific probes demonstrates the existence of at least two more LCA mRNA forms that are generated by differential splicing. A comparison of the human and mouse LCA protein sequences revealed a marked difference only in the extracellular domain.
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DOI: --
发表时间: 1985
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Lefrançois,L;Bevan,MJ
通讯作者: Bevan,MJ
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发表时间: 1987
影响因子: 11.1
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Raschke,WC
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发表时间: 1986
影响因子: 11.1
作者:
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DOI: --
发表时间: 1986
期刊: The Journal of biological chemistry
影响因子: --
作者:
Shackelford,DA;Trowbridge,IS
通讯作者: Trowbridge,IS
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DOI: --
发表时间: 1982
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
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