Severe Acute Respiratory Syndrome Coronavirus 2 in Farmed Mink (Neovison vison), Poland.

Severe Acute Respiratory Syndrome Coronavirus 2 in Farmed Mink (Neovison vison), Poland.
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波兰养殖水貂中的严重急性呼吸道综合征冠状病毒2。

DOI:
10.3201/eid2709.210286
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发表时间:
2021-09
影响因子:
11.8
通讯作者:
Grzybek M
Grzybek M
中科院分区:
医学2区
文献类型:
--
作者:
Rabalski L;Kosinski M;Smura T;Aaltonen K;Kant R;Sironen T;Szewczyk B;Grzybek M

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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是冠状病毒病的病原体,自2019年12月以来在全球范围内传播。该病毒在实验条件下可以感染不同的动物物种,欧洲和其他地区毛皮养殖场的水貂容易受到SARS-CoV-2感染。我们调查了来自波兰北部农场的 91 只水貂的 SARS-CoV-2 感染情况。通过逆转录 PCR、抗原检测和新一代测序,我们确认 15 只动物的 SARS-CoV-2 呈阳性。我们通过对完整病毒基因组进行测序验证了这一发现,并通过刺突蛋白(G75V 和 C1247F)的完整基因组序列确认了一种具有零星突变的病毒变种。我们无法找到同时包含这两种突变的其他 SARS-CoV-2 序列。应通过兽医检查进行国家范围的监测,以在其他水貂养殖场检测 SARS-CoV-2。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of coronavirus disease and has been spreading worldwide since December 2019. The virus can infect different animal species under experimental conditions, and mink on fur farms in Europe and other areas are susceptible to SARS-CoV-2 infection. We investigated SARS-CoV-2 infection in 91 mink from a farm in northern Poland. Using reverse transcription PCR, antigen detection, and next-generation sequencing, we confirmed that 15 animals were positive for SARS-CoV-2. We verified this finding by sequencing full viral genomes and confirmed a virus variant that has sporadic mutations through the full genome sequence in the spike protein (G75V and C1247F). We were unable to find other SARS-CoV-2 sequences simultaneously containing these 2 mutations. Country-scale monitoring by veterinary inspection should be implemented to detect SARS-CoV-2 in other mink farms.
SARS-COV-2在人类和貂皮之间的貂皮农场上传播,然后回到人类。
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