Improved blood suppression in three-dimensional (3D) fast spin-echo (FSE) vessel wall imaging using a combination of double inversion-recovery (DIR) and diffusion sensitizing gradient (DSG) preparations.
Improved blood suppression in three-dimensional (3D) fast spin-echo (FSE) vessel wall imaging using a combination of double inversion-recovery (DIR) and diffusion sensitizing gradient (DSG) preparations.
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DOI：
10.1002/jmri.22042
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Nayak KS
中科院分区：
文献类型：
--
作者：
Makhijani MK;Hu HH;Pohost GM;Nayak KS
通过使用由双反转恢复（DSG）和扩散敏化梯度（DSG）组成的混合制备，在三维内容积快速自旋回波（3D IV-FSE）颈动脉血管壁成像中提供改善的血液抑制。多对比度黑血MRI广泛用于血管壁成像和动脉粥样硬化斑块成分的表征。当使用3D体积成像技术时，血液抑制是困难的。由于血液自旋的不完全替换，DSG方法不能提供稳健的血液抑制，并且DSG方法损害血管壁信号，降低了腔壁对比噪声比效率（CNReff）。在这项工作中，开发了一种混合型血管造影剂+ DSG制剂，并对3D IV-FSE成像中的血液抑制、血管壁信号保留和血管壁对比度进行了优化。心脏门控T1加权颈动脉血管壁图像在80秒内获得5名志愿者，空间分辨率为0.5 × 0.5 × 2.5 mm 3。来自健康志愿者的数据表明，与单独的标准DSG和标准DSG方法相比，所提出的方法在血液抑制和腔壁CNReff方面产生了统计学显著（P < 0.01）的改善。联合使用血管造影剂和DSG制剂可改善3D IV-FSE血管壁成像的血液抑制和管腔壁CNReff。
To provide improved blood suppression in three-dimensional inner-volume fast spin-echo (3D IV-FSE) carotid vessel wall imaging by using a hybrid preparation consisting of double inversion-recovery (DIR) and diffusion sensitizing gradients (DSG). Multicontrast black-blood MRI is widely used for vessel wall imaging and characterization of atherosclerotic plaque composition. Blood suppression is difficult when using 3D volumetric imaging techniques. DIR approaches do not provide robust blood suppression due to incomplete replacement of blood spins, and DSG approaches compromise vessel wall signal, reducing the lumen-wall contrast-to-noise ratio efficiency (CNReff). In this work a hybrid DIR + DSG preparation is developed and optimized for blood suppression, vessel wall signal preservation, and vessel-wall contrast in 3D IV-FSE imaging. Cardiac gated T1-weighted carotid vessel wall images were acquired in five volunteers with 0.5 × 0.5 × 2.5 mm3 spatial resolution in 80 seconds. Data from healthy volunteers indicate that the proposed method yields a statistically significant (P < 0.01) improvement in blood suppression and lumen-wall CNReff compared to standard DIR and standard DSG methods alone. A combination of DIR and DSG preparations can provide improved blood suppression and lumen-wall CNReff for 3D IV-FSE vessel wall imaging.
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DOI：
10.1161/01.atv.19.11.2756
发表时间：
1999-11-01
影响因子：
8.7
作者：
Shinnar, M;Fallon, JT;Fuster, V
通讯作者：
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影响因子：
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影响因子：
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