A combined fMRI study of typed spelling and reading.
A combined fMRI study of typed spelling and reading.
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DOI：
10.1016/j.neuroimage.2010.11.042
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发表时间：
2011-03-15
期刊：
影响因子：
5.7
通讯作者：
Eden GF
中科院分区：
文献类型：
--
作者：
Purcell JJ;Napoliello EM;Eden GF
在这项研究中，我们采用了一种新技术，通过让受试者在功能磁共振成像兼容的 QWERTY 键盘上触摸单个单词来检查书面拼写的神经基础。此外，在同一组参与者中，我们确定与打字拼写相关的任务相关信号变化是否也与阅读信号变化共定位或分离。特别令人感兴趣的是左额下回、左顶叶下叶以及左枕颞叶皮层中被称为视觉词形区（VWFA）的区域，每个区域都与拼写和阅读相关。我们的结果显示，打字拼写与左半球区域网络相关，其中包括额下回、顶内沟、颞下/梭状回，以及埃克斯纳区附近的额上/中回区域。与拼写和阅读相关的激活的联合分析显示，左额下回和枕颞叶皮层存在显着重叠。有趣的是，在 VWFA 的外侧和上方的枕颞皮层中，我们发现了一个与拼写选择性相关的区域，正如两个任务的直接比较所揭示的那样。这些结果表明，打字拼写主要激活左半球网络，其中一部分与拼写和阅读功能相关。进一步的分析表明，左侧枕颞叶皮层包含具有联合和可分离激活模式的拼写和阅读区域。
In this study we employed a novel technique to examine the neural basis of written spelling by having subjects touch-type single words on an fMRI compatible QWERTY keyboard. Additionally, in the same group of participants we determined if task-related signal changes associated with typed spelling were also co-localized with or separate from those for reading. Of particular interest were the left inferior frontal gyrus, left inferior parietal lobe as well as an area in the left occipitotemporal cortex termed the Visual Word Form Area (VWFA), each of which have been associated with both spelling and reading. Our results revealed that typed spelling was associated with a left hemisphere network of regions which included the inferior frontal gyrus, intraparietal sulcus, inferior temporal/fusiform gyrus, as well as a region in the superior/middle frontal gyrus, near Exner's area. A conjunction analysis of activation associated with spelling and reading revealed a significant overlap in the left inferior frontal gyrus and occipitotemporal cortex. Interestingly, within the occipitotemporal cortex just lateral and superior to the VWFA we identified an area that was selectively associated with spelling, as revealed by a direct comparison of the two tasks. These results demonstrate that typed spelling activates a predominantly left hemisphere network, a subset of which is functionally relevant to both spelling and reading. Further analysis revealed that the left occipitotemporal cortex contains regions with both conjoint and dissociable patterns of activation for spelling and reading.
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