Trends in and Predictors of Depression Among Participants in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
Trends in and Predictors of Depression Among Participants in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
复制标题
DOI：
10.1016/j.ajo.2018.09.015
复制
发表时间：
2019-01
影响因子：
4.2
通讯作者：
Gillespie BW
中科院分区：
文献类型：
--
作者：
Musch DC;Niziol LM;Janz NK;Gillespie BW
描述青光眼初始治疗协作研究（CIGTS）参与者中青光眼诊断后抑郁症状的纵向趋势和预测因素。使用临床试验随访数据的队列研究。从1993年10月至1997年4月，在美国14个临床中心招募了607例新诊断的开角型青光眼患者，随机分为药物治疗组和手术治疗组，每6个月随访一次，随访至2004年。研究了三个结局指标：总体CES-D抑郁评分、轻度或重度抑郁（CES-D评分≥7）的存在和支持的抑郁症状数量。平均基线CES-D评分为2.4（SD=3.8），12.5%的受试者报告了与轻度或重度抑郁相关的抑郁症，55.3%的受试者报告了至少一种抑郁症状。治疗后一年，抑郁指标下降（分别为1.5%、6.7%和38.4%），此后略有下降。预测轻度或重度抑郁的基线因素包括视觉相关生活质量（VRQOL）较差（比值比，OR=2.41）、女性（OR=1.42）、年龄较小（每10岁的OR =1.24）和高中教育程度（OR=2.93）;其他结局显示了相似的结果。在治疗开始后的第一年内，抑郁症的发生率显著下降，但在VRQOL受损的患者中升高。鉴于抑郁症可能会降低治疗依从性，从而增加青光眼进展的风险，眼科护理提供者应询问患者有关抑郁症状，在适当时提供保证，并在必要时进行转诊。
To characterize longitudinal trends and factors predictive of depressive symptoms following glaucoma diagnosis in Collaborative Initial Glaucoma Treatment Study (CIGTS) participants. Cohort study using follow up data from a clinical trial. 607 participants with newly-diagnosed open-angle glaucoma were enrolled at 14 clinical centers in the United States from October 1993 through April 1997, randomized to treatment with medication or surgery, and followed every 6 months through 2004.The 8-item Center for Epidemiologic Studies Depression Scale (CES-D) was administered at baseline and follow-up visits. Three outcome measures were investigated: overall CES-D depression score, presence of mild or worse depression (CES-D score≥7), and number of depressive symptoms endorsed. The average baseline CES-D score was 2.4 (SD=3.8), 12.5% of subjects reported symptomatology associated with mild or worse depression, and 55.3% reported at least one depressive symptom. By one-year post-treatment, depression measures decreased (1.5, 6.7%, and 38.4%, respectively), with modest decreases thereafter. Baseline factors predictive of mild or worse depression included worse vision-related quality of life (VRQOL) (odds ratio, OR=2.41), female sex (OR=1.42), younger age (OR per 10 years younger=1.24), and <high- school education (OR=2.93); other outcomes showed similar results. Depressive symptomatology decreased considerably during the first year after treatment initiation, but was elevated in those with impaired VRQOL. Given the potential of depression to reduce treatment adherence and thus increase the risk of glaucoma progression, eye-care providers should ask patients about depressive symptoms, provide reassurance when appropriate, and make referrals as necessary.
登录
查看更多内容
影响因子：
--
作者：
BLAND, JM;ALTMAN, DG
通讯作者：
ALTMAN, DG
影响因子：
4.6
作者：
Schweitzer, I;Maguire, K;Tuckwell, V
通讯作者：
Tuckwell, V
影响因子：
13.7
作者：
Lin, Herng-Ching;Chien, Ching-Wen;Ho, Jau-Der
通讯作者：
Ho, Jau-Der
影响因子：
4.2
作者：
Jampel, Henry D.;Frick, Kevin D.;Lichter, Paul R.
通讯作者：
Lichter, Paul R.
影响因子：
13.7
作者：
Janz, Nancy K.;Wren, Patricia A.;Lichter, Paul R.
通讯作者：
Lichter, Paul R.