The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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DOI：
10.1186/s12943-015-0361-x
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发表时间：
2015-04-17
期刊：
影响因子：
37.3
通讯作者：
Zhao KN
中科院分区：
文献类型：
--
作者：
Zhang L;Wu J;Ling MT;Zhao L;Zhao KN
人类乳头瘤病毒（hpv）的感染导致多种癌症的发展，占所有人类癌症的5%。一个突出的例子是宫颈癌，它是全世界妇女癌症死亡的主要原因之一。已经确定HPV感染诱导的肿瘤的发生和进展是由两个致癌基因E6和E7的持续表达驱动的。E6和E7的表达不仅抑制了肿瘤抑制因子p53和Rb，而且还改变了可能对转化同样重要的其他信号通路。在这些途径中，磷脂酰肌醇3-激酶(PI3K)/Akt/哺乳动物雷帕霉素靶蛋白（mTOR）信号级联通过多种细胞和分子事件在hpv诱导的癌变中起着非常重要的作用。在这篇综述中，我们总结了HPV诱导的癌症中PI3K/Akt/mTOR信号的频繁扩增，并讨论了HPV致癌基因E6/E7/E5如何激活PI3K/Akt/mTOR信号通路来调节肿瘤的发生和进展并影响患者的预后。我们对PI3K/Akt/mTOR信号通路参与hpv转导细胞的永生化和致癌机制的理解的提高，将有助于制定预防和治疗hpv诱导的癌症的新策略。
Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by HPV infection is driven by the sustained expression of two oncogenes E6 and E7. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways that may be equally important for transformation. Among these pathways, the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling cascade plays a very important role in HPV-induced carcinogenesis by acting through multiple cellular and molecular events. In this review, we summarize the frequent amplification of PI3K/Akt/mTOR signals in HPV-induced cancers and discuss how HPV oncogenes E6/E7/E5 activate the PI3K/Akt/mTOR signalling pathway to modulate tumor initiation and progression and affect patient outcome. Improvement of our understanding of the mechanism by which the PI3K/Akt/mTOR signalling pathway contributes to the immortalization and carcinogenesis of HPV-transduced cells will assist in devising novel strategies for preventing and treating HPV-induced cancers.
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影响因子：
--
作者：
Cichon AC;Pickard A;McDade SS;Sharpe DJ;Moran M;James JA;McCance DJ
通讯作者：
McCance DJ
影响因子：
7.2
作者：
Ahn, Jiwon;Won, Misun;Chung, Kyung-Sook
通讯作者：
Chung, Kyung-Sook
影响因子：
6.2
作者：
Chang, Yih-Hsin;Yu, Chen-Wei;Shiau, Ming-Yuh
通讯作者：
Shiau, Ming-Yuh
乳腺上皮细胞转化：细胞培养和小鼠模型的见解。
影响因子：
7.4
作者：
Dimri, G;Band, H;Band, V
通讯作者：
Band, V
影响因子：
2.4
作者：
Borzacchiello, G.;Mogavero, S.;Roperto, F.
通讯作者：
Roperto, F.