Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker.

Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker.
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DOI:
10.1038/s41598-021-99684-0
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发表时间:
2021-10-11
期刊:
影响因子:
4.6
通讯作者:
Aguirre GK
Aguirre GK
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Vincent J;Haggerty EB;Brainard DH;Aguirre GK

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除了视杆和视锥光感受器之外,视网膜还含有固有光敏视网膜神经节细胞(ipRGC)。这些细胞表达色素黑视蛋白,并且已知参与反射性视觉功能,例如瞳孔反应和昼夜节律的光诱导。ipRGC可能通过向膝状体-纹状体通路提供独立的信号,或者通过与“经典”视网膜神经节细胞相互作用并因此修改由“经典”视网膜神经节细胞产生的信号来促进有意识的视觉感知,所述“经典”视网膜神经节细胞组合联合收割机和对比锥输入。在这里,我们通过询问黑视素刺激的350%变化是否改变了检测亮度闪烁的心理物理灵敏度来测试相互作用的存在。在实验1中,我们测试了三名参与者在适应不同程度的强直性黑视素刺激背景后检测亮度闪烁的阈值变化。在实验2和3中,重复该测试,但现在是针对在黑视蛋白刺激的瞬态基座上呈现的亮度闪烁。在这三个实验中,没有发现黑视蛋白刺激对阈值闪烁敏感性的影响。我们的结果表明,即使黑视蛋白刺激的大变化也不会影响近阈值的视锥介导的视觉感知。
In addition to the rod and cone photoreceptors the retina contains intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells express the photopigment melanopsin and are known to be involved in reflexive visual functions such as pupil response and photo-entrainment of the circadian rhythm. It is possible that the ipRGCs contribute to conscious visual perception, either by providing an independent signal to the geniculo-striate pathway, or by interacting with and thus modifying signals arising from “classical” retinal ganglion cells that combine and contrast cone input. Here, we tested for the existence of an interaction by asking if a 350% change in melanopsin stimulation alters psychophysical sensitivity for the detection of luminance flicker. In Experiment 1, we tested for a change in the threshold for detecting luminance flicker in three participants after they adapted to backgrounds with different degrees of tonic melanopsin stimulation. In Experiments 2 and 3, this test was repeated, but now for luminance flicker presented on a transient pedestal of melanopsin stimulation. Across the three experiments, no effect of melanopsin stimulation upon threshold flicker sensitivity was found. Our results suggest that even large changes in melanopsin stimulation do not affect near-threshold, cone-mediated visual perception.
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