The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants.
The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants.
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DOI：
10.1371/journal.pone.0187982
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Anderson KN
中科院分区：
文献类型：
--
作者：
Cassidy S;Trenell MI;Anderson KN
用于治疗慢性非癌症疼痛的药物处方显着增加。在英国人口样本中，我们旨在评估服用这些慢性止痛药的人的心脏代谢 (CM) 健康状况。来自英国生物银行队列的 133,401 名参与者接受了研究。将服用慢性疼痛药物和 CM 药物的患者与仅服用 CM 药物的患者的 BMI、腰围厘米和高血压进行比较。控制了多个混杂因素。与服用 CM 药物的患者相比，服用阿片类药物和 CM 药物的患者 CM 健康状况最差，报告肥胖、“极高风险”腰围和高血压的几率分别增加 95%、82% 和 63%（OR [95% CI] 1.95 [1.75–2.17]、1.82 [1.63–2.03]、1.63 [1.45–1.84]）独自一人。服用神经性疼痛药物和 CM 药物的患者也表现出比仅服用 CM 药物的患者更差的 CM 特征。治疗慢性疼痛和睡眠的药物对 CM 健康和肥胖的影响引起了此类药物的关注，这些药物最近被标记为形成依赖性的药物。这项横断面研究的结果值得进一步调查，并为缩短这些药物处方的呼吁提供了进一步的支持。
There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications. 133,401 participants from the UK Biobank cohort were studied. BMI, waist cm and hypertension were compared between those on drugs prescribed for chronic pain and CM drugs to those on CM drugs only. Multiple confounders were controlled for. Those taking opiates and CM drugs had the worst CM health profile with a 95%, 82% and 63% increased odds of reporting obesity, ‘very high risk’ waist circumference and hypertension, respectively (OR [95% CI] 1.95 [1.75–2.17], 1.82 [1.63–2.03], 1.63 [1.45–1.84]), compared to those on CM drugs alone. Those taking neuropathic pain medications and CM drugs also demonstrate worse CM profile than those taking CM drugs only. The impact of medications for chronic pain and sleep upon CM health and obesity is of concern for these classes of drugs which have been recently labelled as dependency forming medications. The results from this cross sectional study warrants further investigation and adds further support to calls for these medications to be prescribed for shorter periods.
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影响因子：
2.6
作者：
Quilici S;Chancellor J;Löthgren M;Simon D;Said G;Le TK;Garcia-Cebrian A;Monz B
通讯作者：
Monz B
影响因子：
16.2
作者：
Freeman R;Durso-Decruz E;Emir B
通讯作者：
Emir B
影响因子：
4.2
作者：
Colameco, Stephen;Coren, Joshua S.;Ciervo, Carman A.
通讯作者：
Ciervo, Carman A.
影响因子：
16.2
作者：
Hardy, Thomas;Sachson, Richard;Boulton, Andrew J. M.
通讯作者：
Boulton, Andrew J. M.
影响因子：
3.6
作者：
Ruscitto, A.;Smith, B. H.;Guthrie, B.
通讯作者：
Guthrie, B.