Remote effects of intermittent theta burst stimulation of the human pharyngeal motor system.
Remote effects of intermittent theta burst stimulation of the human pharyngeal motor system.
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DOI：
10.1111/j.1460-9568.2012.08157.x
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Hamdy S
中科院分区：
文献类型：
--
作者：
Mistry S;Michou E;Rothwell J;Hamdy S
间歇性Theta爆发刺激（iTBS）是一种新型的非侵入性脑刺激形式，能够促进人类初级运动皮层的兴奋性，具有治疗神经系统疾病（如多发性硬化症）的治疗潜力。本研究的目的是评估iTBS对人类咽运动系统皮质特性的影响。经颅磁刺激（TMS）诱发的咽部运动反应通过吞咽的腔内导管记录，并用于评估15名健康成人（9名男性/6名女性，22-59岁）在iTBS之前和之后长达90分钟的两个半球中的咽部运动皮质通路。活性/假iTBS包括600个间歇性重复TMS脉冲，以双盲伪随机顺序在每个半球上在分开的日子至少间隔1周递送。拇短展肌（APB）记录用作对照。采用重复测量方差分析比较半球介入数据与假手术数据。以刺激器输出的43 ± 1%的平均强度输送iTBS。与假手术组相比，iTBS组咽部投射较强的半球仅在iTBS后60-90 min引起对侧较弱投射的反应增加（最大值54 ± 19%，P ≤ 0.007），而较强的半球反应无变化。相比之下，iTBS到较弱的预测没有显着的影响（P = 0.39），对任何半球。在所有研究组中，APB应答同样没有显著变化（P = 0.78）。我们得出结论，iTBS可以诱导皮质延髓兴奋性的远程变化。虽然进一步的研究将阐明这些变化的程度，但iTBS有望成为单侧脑损伤后吞咽困难的潜在治疗方法。
Intermittent theta burst stimulation (iTBS) is a novel, non-invasive form of brain stimulation capable of facilitating excitability of the human primary motor cortex with therapeutic potential in the treatment of neurological conditions, such as multiple sclerosis. The objectives of this study were to evaluate the effects of iTBS on cortical properties in the human pharyngeal motor system. Transcranial magnetic stimulation (TMS)-evoked pharyngeal motor responses were recorded via a swallowed intra-luminal catheter and used to assess motor cortical pathways to the pharynx in both hemispheres before and for up to 90 min after iTBS in 15 healthy adults (nine male/six female, 22–59 years old). Active/sham iTBS comprised 600 intermittent repetitive TMS pulses, delivered in a double-blind pseudo-randomised order over each hemisphere on separate days at least 1 week apart. Abductor pollicis brevis (APB) recordings were used as control. Hemispheric interventional data were compared with sham using repeated-measures anova. iTBS was delivered at an average intensity of 43 ± 1% of stimulator output. Compared with sham, iTBS to the hemisphere with stronger pharyngeal projections induced increased responses only in the contralateral weaker projection 60–90 min post-iTBS (maximum 54 ± 19%, P ≤ 0.007), with no change in stronger hemisphere responses. By contrast, iTBS to weaker projections had no significant effects (P = 0.39) on either hemisphere. APB responses similarly did not change significantly (P = 0.78) across all study arms. We conclude that iTBS can induce remote changes in corticobulbar excitability. While further studies will clarify the extent of these changes, iTBS holds promise as a potential treatment for dysphagia after unilateral brain damage.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
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DOI：
10.12659/msm.881446
发表时间：
2011-02-25
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Szaflarski JP;Vannest J;Wu SW;DiFrancesco MW;Banks C;Gilbert DL
通讯作者：
Gilbert DL
影响因子：
29.4
作者：
Singh, Saul;Mistry, Satish;Hamdy, Shaheen
通讯作者：
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影响因子：
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7.7
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