Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia.
Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia.
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DOI：
10.1097/fm9.0000000000000132
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Chen DB
中科院分区：
文献类型：
--
作者：
Li Y;Han B;Salmeron AG;Bai J;Chen DB
正常妊娠与雌激素生物合成的显著增加有关，其作用被认为是提高子宫血流，以促进气体（O2和CO2）的双向母胎交换，输送营养物质，并排出废物，以支持胎儿发育和存活。妊娠期子宫血流受限是先兆子痫伴胎儿生长受限的主要原因，因此子宫血流动力学研究有望为先兆子痫治疗干预的靶点提供信息。长期以来，妊娠期雌激素诱导的子宫血管舒张的机制一直被认为是内皮细胞产生一氧化氮的增加，但针对这一主导子宫血流动力学的途径的临床试验没有取得成功。新出现的证据表明，硫化氢在调节妊娠期和先兆子痫的子宫血流动力学中具有一种新的促血管生成血管舒张作用，这引发了围产期研究的新领域，即寻找妊娠疾病特别是先兆子痫和宫内生长受限的替代途径。本文旨在总结一氧化氮途径，并讨论新出现的硫化氢途径在调节雌激素诱导的子宫血管舒张妊娠和先兆子痫。
Normal pregnancy is associated with dramatically increased estrogen biosynthesis whose role is believed to raise uterine blood flow to facilitate the bi-directional maternal-fetal exchanges of gases (O2 and CO2), to deliver nutrients, and exhaust wastes to support fetal development and survival. Constrained uterine blood flow in pregnancy is a leading cause of preeclampsia with fetal growth restriction, rendering investigations of uterine hemodynamics to hold a high promise to inform pathways as targets for therapeutic interventions for preeclampsia. The mechanisms of estrogen-induced uterine vasodilation in pregnancy have long been attributed to enhanced endothelium production of nitric oxide, but clinical trials targeting this pathway that dominates uterine hemodynamics have achieved no to little success. Emerging evidence has recently shown a novel proangiogenic vasodilatory role of hydrogen sulfide in regulating uterine hemodynamics in pregnancy and preeclampsia, provoking a new field of perinatal research in searching for alternative pathways for pregnancy disorders especially preeclampsia and intrauterine growth restriction. This minireview is intended to summarize the nitric oxide pathway and to discuss the emerging hydrogen sulfide pathway in modulating estrogen-induced uterine vasodilation in pregnancy and preeclampsia.
DOI：
10.1177/1933719108319160
发表时间：
2008-09
期刊：
Reproductive sciences (Thousand Oaks, Calif.)
影响因子：
--
作者：
Rosenfeld CR;Word RA;DeSpain K;Liu XT
通讯作者：
Liu XT