Cell senescence is an antiviral defense mechanism.
Cell senescence is an antiviral defense mechanism.
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细胞衰老是一种抗病毒防御机制。
DOI：
10.1038/srep37007
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发表时间：
2016-11-16
影响因子：
4.6
通讯作者：
Rivas C
中科院分区：
文献类型：
--
作者：
Baz-Martínez M;Da Silva-Álvarez S;Rodríguez E;Guerra J;El Motiam A;Vidal A;García-Caballero T;González-Barcia M;Sánchez L;Muñoz-Fontela C;Collado M;Rivas C
细胞衰老通常被认为是由施加细胞应激的条件触发的保护机制。持续增殖、DNA损伤剂或活化的癌基因是众所周知的细胞衰老的活化剂。除了特征性的稳定细胞周期停滞，这种反应还涉及称为衰老相关分泌表型（SASP）的促炎表型。这一点，加上众所周知的一些肿瘤病毒对衰老途径的干扰，导致了这样的假设：衰老也可能是宿主细胞对抗病毒反应的一部分。在这里，我们评估这一假设使用水泡性口炎病毒（VSV）作为模型。我们的研究结果表明，VSV复制显着受损的主要和肿瘤衰老细胞相比，非衰老细胞，和独立的刺激用于触发衰老。重要的是，我们还证明了衰老对体内VSV的保护作用。最后，我们的研究结果确定了SASP作为体外细胞衰老产生的抗病毒防御的主要贡献者，并指出了激活和招募免疫系统以清除感染的作用。因此，我们的研究表明，细胞衰老也是一种天然的抗病毒防御机制。
Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus. Here, we evaluate this hypothesis using vesicular stomatitis virus (VSV) as a model. Our results show that VSV replication is significantly impaired in both primary and tumor senescent cells in comparison with non-senescent cells, and independently of the stimulus used to trigger senescence. Importantly, we also demonstrate a protective effect of senescence against VSV in vivo. Finally, our results identify the SASP as the major contributor to the antiviral defense exerted by cell senescence in vitro, and points to a role activating and recruiting the immune system to clear out the infection. Thus, our study indicates that cell senescence has also a role as a natural antiviral defense mechanism.
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影响因子：
3.7
作者：
HAYFLICK, L;MOORHEAD, PS
通讯作者：
MOORHEAD, PS
影响因子：
3.3
作者：
Moiseeva, O;Mallette, FA;Ferbeyre, G
通讯作者：
Ferbeyre, G
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
4
作者：
Alexander, Eva;Hildebrand, Dominic G.;Essmann, Frank
通讯作者：
Essmann, Frank
影响因子：
5.4
作者：
Balachandran, S;Porosnicu, M;Barber, GN
通讯作者：
Barber, GN