Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles.
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles.
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SARS-COV-2疫苗接种后与B细胞缺陷和免疫谱改变的SARS-COV-2疫苗接种后，HIV中的体液反应减弱。
DOI：
10.1016/j.isci.2022.105862
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发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
McCoy, Laura E.
中科院分区：
文献类型：
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作者：
Touizer, Emma;Alrubayyi, Aljawharah;Ford, Rosemarie;Hussain, Noshin;Gerber, Pehuen Pereyra;Shum, Hiu-Long;Rees-Spear, Chloe;Muir, Luke;Gea-Mallorqui, Ester;Kopycinski, Jakub;Jankovic, Dylan;Jeffery-Smith, Anna;Pinder, Christopher L.;Fox, Thomas A.;Williams, Ian;Mullender, Claire;Maan, Irfaan;Waters, Laura;Johnson, Margaret;Madge, Sara;Youle, Michael;Barber, Tristan J.;Burns, Fiona;Kinloch, Sabine;Rowland-Jones, Sarah;Gilson, Richard;Matheson, Nicholas J.;Morris, Emma;Peppa, Dimitra;McCoy, Laura E.
我们评估了一个队列的人与人类免疫缺陷病毒（PLWH）（n = 110）和HIV阴性对照（n = 64）后，1，2或3 SARS-CoV-2疫苗剂量。在所有时间点，PLWH的中和抗体（nAb）滴度均显著低于HIV阴性对照。我们还观察到PLWH中中和的延迟发展，这是由尖峰特异性记忆B细胞（MBC）的频率降低所支持的。在PLWH中，在第三次疫苗给药后，观察到针对Omicron变体（BA.1）的中和宽度改善，但较低的nAb应答持续存在，并与总体MBC功能障碍相关。相比之下，SARS-CoV-2疫苗接种诱导了强烈的T细胞应答，交叉识别PLWH中的变体。引人注目的是，中和作用低或不存在的个体具有可检测的功能性T细胞应答。在两次SARS-CoV-2疫苗接种后，这些PLWH的循环T滤泡辅助细胞数量减少，CXCR 3 + CD 127 + CD 8 +T细胞群富集。PLWH在SARS-CoV-2疫苗接种后具有较低水平的中和抗体（nAb）延迟产生nAb与较大的记忆B细胞（MBC）干扰相关额外剂量增加nAb滴度和宽度，尽管MBC持续扰动SARS-CoV-2疫苗接种在PLWH中激发了强的T细胞应答PLWH具有刺突特异性T细胞，但没有nAb增加CXCR 3 + CD 127 + CD 8 +T细胞免疫学;病毒学
We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a delayed development of neutralization in PLWH that was underpinned by a reduced frequency of spike-specific memory B cells (MBCs). Improved neutralization breadth was seen against the Omicron variant (BA.1) after the third vaccine dose in PLWH but lower nAb responses persisted and were associated with global MBC dysfunction. In contrast, SARS-CoV-2 vaccination induced robust T cell responses that cross-recognized variants in PLWH. Strikingly, individuals with low or absent neutralization had detectable functional T cell responses. These PLWH had reduced numbers of circulating T follicular helper cells and an enriched population of CXCR3+CD127+CD8+T cells after two doses of SARS-CoV-2 vaccination. PLWH have lower levels of neutralizing antibodies (nAbs) after SARS-CoV-2 vaccination Delayed production of nAbs is associated with greater memory B cell (MBCs) disturbance Additional doses increase nAbs titers and breadth despite persistent MBCs perturbations SARS-CoV-2 vaccination elicits robust T cell responses in PLWH PLWH with spike-specific T cells but no nAbs have increased CXCR3+CD127+CD8+T cells Immunology; Virology
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
3.8
作者：
Casado, Jose L.;Vizcarra, Pilar;Haemmerle, Johannes;Velasco, Hector;Martin-Hondarza, Adrian;Rodriguez-Dominguez, Mario J.;Velasco, Tamara;Martin, Sara;Romero-Hernandez, Beatriz;Fernandez-Escribano, Marina;Vallejo, Alejandro
通讯作者：
Vallejo, Alejandro
DOI：
10.1093/cid/ciac796
发表时间：
2023-01-13
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Bangs DJ;Tsitsiklis A;Steier Z;Chan SW;Kaminski J;Streets A;Yosef N;Robey EA
通讯作者：
Robey EA
mRNA疫苗会诱导SARS-COV-2和关注的变体诱导耐用的免疫记忆。
DOI：
10.1126/science.abm0829
发表时间：
2021-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
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