Pre-existing T cell immunity determines the frequency and magnitude of cellular immune response to two doses of mRNA vaccine against SARS-CoV-2.
Pre-existing T cell immunity determines the frequency and magnitude of cellular immune response to two doses of mRNA vaccine against SARS-CoV-2.
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DOI：
10.1016/j.jvacx.2022.100165
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发表时间：
2022-08
期刊：
影响因子：
3.8
通讯作者：
Vallejo, Alejandro
中科院分区：
文献类型：
--
作者：
Casado, Jose L.;Vizcarra, Pilar;Haemmerle, Johannes;Velasco, Hector;Martin-Hondarza, Adrian;Rodriguez-Dominguez, Mario J.;Velasco, Tamara;Martin, Sara;Romero-Hernandez, Beatriz;Fernandez-Escribano, Marina;Vallejo, Alejandro
在21%和12%的卫生保健工作者（HCW）中观察到对第一/第二剂量mRNA疫苗缺乏CD 4 T细胞应答。由于感染或交叉反应性，在具有预先存在的免疫力的HCW中，T细胞应答的频率/幅度更大。预先存在的免疫力与疫苗接种后特异性抗体产生的幅度相关。关于T细胞对针对SARS-CoV-2的mRNA疫苗缺乏应答的相关因素知之甚少。在61名卫生保健工作者（HCW）的前瞻性队列中，第一剂mRNA BNT 162 b疫苗后分别有21%和16%，第二剂后分别有12%和7%，显示缺乏CD 4+和CD 8 + T细胞应答。由于既往感染（46%）或交叉反应性细胞应答（26%），预先存在的T细胞免疫与随访期间T细胞应答的频率（CD 4 + T细胞，100% vs 82%，两次给药后; p = 0.049）和T细胞应答的幅度显著相关。此外，基线CD 4 + T细胞与第一次和第二次疫苗接种后特异性IgG抗体的滴度呈正相关。我们的数据表明，交叉反应性T细胞与更好的细胞应答以及增强的体液应答相关，并且我们证实了mRNA疫苗接种后体液应答和细胞应答的密切相关性。
Lack of CD4 T-cell response to first/second dose of mRNA vaccine was observed in 21% and 12% of health care workers (HCWs). T-cell response was greater in frequency/magnitude in HCWs with pre-existing immunity, due due to infection or cross-reactivity. Pre-existing immunity correlated with the magnitude of specific antibodies production after vaccination. Little is known about the factors associated with lack of T-cell response to mRNA vaccines against SARS-CoV-2. In a prospective cohort of 61 health care workers (HCWs), 21% and 16% after the first dose of mRNA BNT162b vaccine, and 12% and 7% after the second dose, showed lack of CD4+ and CD8+ T-cell response, respectively. Pre-existing T-cell immunity, due to past infection (46%) or cross-reactive cellular response (26%), was significantly associated with T-cell response in frequency (CD4+ T-cell, 100% vs 82% after two doses; p = 0.049) and in the magnitude of T-cell response during follow up. Furthermore, baseline CD4+ T-cell correlated positively with the titer of specific IgG-antibodies after first and second vaccine dose. Our data demonstrate that cross-reactive T-cells correlate with a better cellular response as well as an enhanced humoral response, and we confirm the close correlation of humoral and cellular response after mRNA vaccination.
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影响因子：
32.4
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