Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms.
Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms.
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DOI：
10.1007/s00127-018-1496-z
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发表时间：
2018-05
影响因子：
4.4
通讯作者：
Zammit S
中科院分区：
文献类型：
--
作者：
Davies J;Sullivan S;Zammit S
调查12岁至18岁的精神病经历和抑郁症状是否与16岁至20岁的一系列功能领域的不良生活结果有关。数据来自英国出生队列ALSPAC。在12岁和18岁时，用半结构化精神病样症状访谈和简短的情绪和感觉问卷对个体进行评估。使用Logistic回归分析探讨16岁至20岁之间的教育、职业、社会功能、物质使用(酒精、大麻、吸烟和其他药物)以及非法行为与结果的关系。所有的关联都根据社会人口和童年的混杂因素以及共同的精神病经历或抑郁症状进行了调整。12岁时的精神病经历和抑郁与16岁到20岁之间较差的教育、职业和社会结果相关；这些都经受住了混淆的调整。12岁时的抑郁症状也与有害饮酒有关。18岁时的精神病经历和抑郁还与其他形式的药物使用和非法行为有关。共病在12岁时影响很小，但与18岁时教育、社会和物质使用结果明显较差有关。青春期精神病经历和抑郁是后来一些不良结果的风险标志，最一致的是教育和就业，但也包括社会损害、有害饮酒和物质使用。这突显了认识青少年精神病理学的重要性，以便能够提供支持，试图将不良后果降至最低。本文的在线版本(10.1007/s00127-0181496-z)包含补充材料，授权用户可以使用。
To investigate whether psychotic experiences and depressive symptoms at ages 12 and 18 years are associated with adverse life outcomes across a range of functional domains between 16 and 20 years of age. Data were gathered from ALSPAC, a UK birth cohort. Individuals were assessed with the semi-structured Psychosis-Like Symptoms Interview and the Short Mood and Feeling Questionnaire at ages 12 and 18 years. Logistic regression was used to explore associations with outcomes in education, occupation, social functioning, substance use (alcohol, cannabis, smoking, and other drugs), and illegal behaviour between the ages of 16 and 20 years. All associations were adjusted for socio-demographic and childhood confounders and for comorbid psychotic experiences or depressive symptoms. Psychotic experiences and depression at age 12 were associated with poorer educational, occupational, and social outcomes between the ages of 16 and 20; these withstood adjustment for confounding. Depressive symptoms at age 12 were also associated with harmful drinking. Psychotic experiences and depression at age 18 were additionally associated with other forms of substance use and illegal behaviour. Comorbidity had little impact at age 12, but was associated with significantly worse educational, social, and substance use outcomes at age 18. Adolescent psychotic experiences and depression represent a risk marker for a number of later adverse outcomes, most consistently with education and employment, but also social impairment, harmful drinking, and substance use. This highlights the importance of recognizing adolescent psychopathology, so that support can be provided to try and minimize adverse outcomes. The online version of this article (10.1007/s00127-018-1496-z) contains supplementary material, which is available to authorized users.
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影响因子：
3.1
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