Mechanical properties of respiratory muscles.
Mechanical properties of respiratory muscles.
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DOI：
10.1002/cphy.c130003
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发表时间：
2013-10
影响因子：
5.8
通讯作者：
Mantilla CB
中科院分区：
文献类型：
--
作者：
Sieck GC;Ferreira LF;Reid MB;Mantilla CB
横纹肌对于肺的通风和维持上呼吸道的通畅是必要的。呼吸肌的基本结构和功能特性与其他横纹肌相似(包括骨骼肌和心脏)。肌节是横纹肌的基本组织单位，肌节蛋白是肌肉纤维被动和主动力学特性的基础。在这方面，不同纤维类型的功能分类为理解呼吸肌的生理特性提供了一个概念性的框架。在肌节内，在横桥水平上粗丝和细丝之间的相互作用提供了力产生和收缩的基本单位。理解肌纤维类型之间独特的功能差异的关键是跨桥招募和循环的差异，这与粗丝中不同的肌球蛋白重链亚型的表达有关。肌纤维的主动力学特性表现为肌浆钙离子与跨桥募集、力产生与肌节长度(也称为跨桥募集)、外部负荷与缩短速度(跨桥循环率)、跨桥循环率与ATP消耗的关系。被动机械性能也是反映肌瘤内以及细胞外基质的粘弹性元件的重要因素。影响呼吸肌功能的疾病可能有一系列潜在的病理生理原因，但它们的表现将取决于它们对这些基本结构的影响。
Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of the upper airway. The basic structural and functional properties of respiratory muscles are similar to those of other striated muscles (both skeletal and cardiac). The sarcomere is the fundamental organizational unit of striated muscles and sarcomeric proteins underlie the passive and active mechanical properties of muscle fibers. In this respect, the functional categorization of different fiber types provides a conceptual framework to understand the physiological properties of respiratory muscles. Within the sarcomere, the interaction between the thick and thin filaments at the level of cross-bridges provides the elementary unit of force generation and contraction. Key to an understanding of the unique functional differences across muscle fiber types are differences in cross-bridge recruitment and cycling that relate to the expression of different myosin heavy chain isoforms in the thick filament. The active mechanical properties of muscle fibers are characterized by the relationship between myoplasmic Ca2+ and cross-bridge recruitment, force generation and sarcomere length (also cross-bridge recruitment), external load and shortening velocity (cross-bridge cycling rate), and cross-bridge cycling rate and ATP consumption. Passive mechanical properties are also important reflecting viscoelastic elements within sarcomeres as well as the extracellular matrix. Conditions that affect respiratory muscle performance may have a range of underlying pathophysiological causes, but their manifestations will depend on their impact on these basic elemental structures.
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影响因子：
5.5
作者：
Argadine, Heather M.;Mantilla, Carlos B.;Sieck, Gary C.
通讯作者：
Sieck, Gary C.
影响因子：
3.3
作者：
Ameredes, BT;Zhan, WZ;Sieck, GC
通讯作者：
Sieck, GC
DOI：
10.1016/0034-5687(73)90050-9
发表时间：
1973-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
BARTLETT, D;REMMERS, JE;GAUTIER, H
通讯作者：
GAUTIER, H
影响因子：
3.3
作者：
BELLEMARE, F;BIGLANDRITCHIE, B
通讯作者：
BIGLANDRITCHIE, B
影响因子：
3.4
作者：
Anderson, J;Li, ZL;Goubel, F
通讯作者：
Goubel, F