Wnt signaling pathways in urological cancers: past decades and still growing.
Wnt signaling pathways in urological cancers: past decades and still growing.
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DOI：
10.1186/1476-4598-11-7
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发表时间：
2012-02-10
期刊：
影响因子：
37.3
通讯作者：
Dahiya R
中科院分区：
文献类型：
--
作者：
Majid S;Saini S;Dahiya R
Wnt信号通路参与了广泛的胚胎构型事件和成年组织内稳态的维持。Wnt途径的病理作用是从研究中发现的，这些研究表明，与突变相关的特定人类癌症的频率很高，这些突变激活了这些途径的转录反应。Wnt信号通路的结构性激活是实体瘤的共同特征，在多种肿瘤的发生、发展和转移中起重要作用。在这篇综述中，Wnt通路将从泌尿系癌症的角度进行讨论，重点放在最近发表的文献上。还将讨论microRNAs(MiRNA)对Wnt信号通路的调节，即修改基因表达谱的小RNA序列。对Wnt信号通路的基本遗传学和生物学的深入了解将为开发新的泌尿系肿瘤的化学预防和治疗策略提供新的见解。
The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to tumor development, progression and metastasis in various cancers. In this review, the Wnt pathway will be covered from the perspective of urological cancers with emphasis placed on the recent published literature. Regulation of the Wnt signaling pathway by microRNAs (miRNA), small RNA sequences that modify gene expression profiles will also be discussed. An improved understanding of the basic genetics and biology of Wnt signaling pathway will provide insights into the development of novel chemopreventive and therapeutic strategies for urological cancers.
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