Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion.
Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion.
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DOI：
10.1007/s00262-020-02603-x
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Gallimore A
中科院分区：
文献类型：
--
作者：
Hughes E;Lauder SN;Smart K;Bloom A;Scott J;Jones E;Somerville M;Browne M;Blainey A;Godkin A;Ager A;Gallimore A
虽然转移性疾病是导致大多数癌症死亡的原因，但在小鼠肿瘤模型中进行的新型免疫疗法测试通常侧重于原发性肿瘤，而不确定这些疗法是否也针对转移性疾病。本研究利用乳腺癌小鼠模型研究了Foxp3+调节性T细胞（Treg）的消耗对肺转移的影响。treg耗竭后，对原发肿瘤产生的免疫应答是限制转移发展的关键决定因素。事实上，原发肿瘤的切除消除了treg对转移的任何影响。此外，虽然由原发肿瘤产生的免疫反应可以阻止转移的发展，但它对控制已建立的疾病几乎没有影响。总的来说，这些数据表明肺中的转移细胞不受原发肿瘤诱导的免疫反应的控制。这些发现表明单独靶向Tregs不足以治疗肺转移瘤。本文的在线版本（10.1007/s00262-020-02603-x）包含补充材料，可供授权用户使用。
Although metastatic disease is responsible for the majority of cancer deaths, tests of novel immunotherapies in mouse tumour models often focus on primary tumours without determining whether these therapies also target metastatic disease. This study examined the impact of depleting Foxp3+ regulatory T cells (Treg), on lung metastases, using a mouse model of breast cancer. After Treg-depletion, generation of an immune response to the primary tumour was a critical determinant for limiting development of metastasis. Indeed, resection of the primary tumour abrogated any effect of Treg-depletion on metastases. In addition, whilst the immune response, generated by the primary tumour, prevented metastases development, it had little impact on controlling established disease. Collectively, the data indicate that metastatic cells in the lung are not controlled by immune responses induced by the primary tumour. These findings indicate that targeting Tregs alone will not suffice for treating lung metastases. The online version of this article (10.1007/s00262-020-02603-x) contains supplementary material, which is available to authorised users.
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影响因子：
32.4
作者：
Joshi NS;Akama-Garren EH;Lu Y;Lee DY;Chang GP;Li A;DuPage M;Tammela T;Kerper NR;Farago AF;Robbins R;Crowley DM;Bronson RT;Jacks T
通讯作者：
Jacks T
DOI：
10.1186/bcr1530
发表时间：
2006
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Fantozzi A;Christofori G
通讯作者：
Christofori G
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
50.3
作者：
Costa, Ana;Kieffer, Yann;Mechta-Grigoriou, Fatima
通讯作者：
Mechta-Grigoriou, Fatima
DOI：
10.1084/jem.20130762
发表时间：
2013-10-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bos PD;Plitas G;Rudra D;Lee SY;Rudensky AY
通讯作者：
Rudensky AY