Efficient mucosal vaccination mediated by the neonatal Fc receptor.
Efficient mucosal vaccination mediated by the neonatal Fc receptor.
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新生儿FC受体介导的有效粘膜疫苗接种。
DOI：
10.1038/nbt.1742
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发表时间：
2011-02
影响因子：
46.9
通讯作者：
中科院分区：
文献类型：
--
作者：
由于80-90%的感染性疾病是在粘膜表面开始的，因此正在寻求预防侵入性粘膜病原体的疫苗策略。然而，我们递送完整疫苗抗原穿过粘膜屏障以诱导有效免疫的能力有限。新生儿Fc受体（FcRn）介导IgG转运穿过粘膜表面的极化上皮细胞。通过模拟粘膜表面的IgG转移，用模型抗原鼻内免疫，与IgG Fc片段融合的单纯疱疹病毒2型（HSV-2）糖蛋白gD，与佐剂CpG组合，导致用毒性HSV-2阴道内攻击的野生型而非FcRn敲除小鼠的完全保护186。该免疫策略诱导有效的粘膜和全身性抗体、B和T细胞免疫应答，包括记忆免疫应答，其在接种后至少6个月保持稳定，并为大多数动物提供保护。这些结果表明，FcRn-IgG跨细胞转运途径可能代表了一种新的粘膜疫苗递送途径，用于针对丰富的粘膜病原体的亚单位疫苗。
Vaccine strategies to prevent invasive mucosal pathogens are being sought because 80–90% of infectious diseases are initiated at mucosal surfaces. However, our ability to deliver an intact vaccine antigen across a mucosal barrier for induction of effective immunity is limited. The neonatal Fc receptor (FcRn) mediates the transport of IgG across polarized epithelial cells lining mucosal surfaces. By mimicking IgG transfer at mucosal surfaces, intranasal immunization with a model antigen, herpes simplex virus type-2 (HSV-2) glycoprotein gD fused with an IgG Fc fragment, in combination with the adjuvant CpG, resulted in complete protection of wild type, but not FcRn knockout, mice that were intravaginally challenged with virulent HSV-2 186. This immunization strategy induced efficient mucosal and systemic antibody, B and T cell immune responses, including memory immune responses, which remained stable at least 6 months post-vaccination and conferred protection for a majority of animals. These results demonstrate that the FcRn-IgG transcellular transport pathway may represent a novel mucosal vaccine delivery route for a subunit vaccine against abundant mucosal pathogens.
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影响因子：
4.4
作者：
Lindqvist, Madelene;Persson, Josefine;Harandi, Ali M.
通讯作者：
Harandi, Ali M.
影响因子：
3.7
作者：
Milligan, GN;Dudley-McClain, KL;Young, CG
通讯作者：
Young, CG
DOI：
10.1084/jem.20070607
发表时间：
2007-11-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nochi T;Yuki Y;Matsumura A;Mejima M;Terahara K;Kim DY;Fukuyama S;Iwatsuki-Horimoto K;Kawaoka Y;Kohda T;Kozaki S;Igarashi O;Kiyono H
通讯作者：
Kiyono H
影响因子：
3.7
作者：
ChangLai, SP;Hung, WT;Liao, KK
通讯作者：
Liao, KK
DOI：
10.1084/jem.20062381
发表时间：
2007-03-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dooms H;Wolslegel K;Lin P;Abbas AK
通讯作者：
Abbas AK