Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine.
Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine.
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用于再生医学的靶向近红外荧光成像。
DOI：
10.1007/s13770-019-00219-6
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发表时间：
2019
影响因子：
3.6
通讯作者：
Choi,HakSoo
中科院分区：
文献类型：
--
作者：
Yang,Chengeng;Park,GKate;McDonald,EricJ;Choi,HakSoo
在过去的三十年里，组织工程和再生医学的发展在损伤组织的诊断和治疗方法方面取得了很大的进展。然而，由于对组织再生过程的了解有限，再生医学仍然不是患者的一线治疗方法。因此，制定分子成像策略并结合合适的造影剂来验证受损组织的治疗进展是先决条件。方法综述近红外（NIR）造影剂的研究进展及其在生物医学上的应用，以标记细胞和支架，以及监测生物体内天然组织的治疗进展。本文还从理化性质和光学性质等方面讨论了组织工程和再生医学用近红外造影剂的设计考虑。结果应用近红外成像系统和靶向造影剂可提供高分辨率和高灵敏度的成像，跟踪/监测治疗期间给药细胞的活力、植入支架的降解率以及周围细胞的组织生长和整合情况。结论近红外荧光成像技术联合靶向造影剂可监测移植细胞和支架的治疗效果，在再生医学中发挥重要作用，促进细胞疗法的发展，促进其成功临床转化。
BackgroundAdvances in tissue engineering and regenerative medicine over the last three decades have made great progress in the development of diagnostic and therapeutic methodologies for damaged tissues. However, regenerative medicine is still not the first line of treatment for patients due to limited understanding of the tissue regeneration process. Therefore, it is prerequisite to develop molecular imaging strategies combined with appropriate contrast agents to validate the therapeutic progress of damaged tissues.MethodsThe goal of this review is to discuss the progress in the development of near-infrared (NIR) contrast agents and their biomedical applications for labeling cells and scaffolds, as well as monitoring the treatment progress of native tissue in living organisms. We also discuss the design consideration of NIR contrast agents for tissue engineering and regenerative medicine in terms of their physicochemical and optical properties.ResultsThe use of NIR imaging system and targeted contrast agents can provide high-resolution and high sensitivity imaging to track/monitor thein vivofate of administered cells, the degradation rate of implanted scaffolds, and the tissue growth and integration of surrounding cells during the therapeutic period.ConclusionNIR fluorescence imaging techniques combined with targeted contrast agents can play a significant role in regenerative medicine by monitoring the therapeutic efficacy of implanted cells and scaffolds which would enhance the development of cell therapies and promote their successful clinical translations.
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