Prognostic value of fractalkine/CX3CL1 concentration in patients with acute myocardial infarction treated with primary percutaneous coronary intervention
Prognostic value of fractalkine/CX3CL1 concentration in patients with acute myocardial infarction treated with primary percutaneous coronary intervention
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fractalkine/CX3CL1浓度对接受直接经皮冠状动脉介入治疗的急性心肌梗死患者的预后价值
DOI：
10.1016/j.cyto.2018.10.006
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发表时间：
2019-01
期刊：
影响因子：
3.8
通讯作者：
Wang Junhong
中科院分区：
文献类型：
--
作者：
Xu Bing;Qian Yanxia;Zhao Yingming;Fang Zhen;Tang Kangting;Zhou Ningtian;Li Dianfu;Wang Junhong
BackgroundRecent studies demonstrated that fractalkine (FKN) is critically involved in the regulation of inflammation and cardiac function.ObjectiveThis study aimed to investigate the prognostic value of circulating FKN in patients with ST-elevated acute myocardial infarction (STEMI) after primary PCI.MethodsWe enrolled ninety consecutive STEMI patients and investigated the association of circulating FKN with myocardial salvage and the occurrence of major adverse cardiac events (MACE) after PCI.ResultsDuring a median follow-up of 387 days, total 15 MACE (16.67%) were registered in the study population. Patients with MACE were more likely to be occurred in elderly patients with 3-vessel disease. Correlation analysis demonstrated the level of FKN at day 1 after PCI (FKN@day-1) not only significantly correlated with the levels of hs-TnT at day 7 after PCI (R2= 0.06; p = 0.02) but inversely correlated with the measurements of LVEF at 1-month observation (R2= 0.10; p = 0.00). Kaplan-Meier survival analyses further revealed that patients with the level of FKN@day-1 above the median had a higher incidence of MACE compared with those whose FKN@day-1 levels below the median (log-rank test x2= 13.29, p < 0.001). In addition, multivariate Cox regression analysis demonstrated that FKN@day-1 was an independent predictor of MACE (hazard ratio: 4.63; 95% confidence interval: 1.53–14.01; p = 0.00), together with WBC count and 3-vessel disease for STEMI patients.ConclusionsOur study demonstrates that FKN@day-1 is negative correlated with myocardial salvage after acute myocardial infarction and might be a valuable prognostic marker of MACE in patients with STEMI undergone PCI.
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影响因子：
2.1
作者：
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通讯作者：
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影响因子：
39.3
作者：
T. Koenig;D. Sedding;H. Wester;T. Derlin
通讯作者：
T. Koenig;D. Sedding;H. Wester;T. Derlin
影响因子：
5.4
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Sanak M
影响因子：
3.3
作者：
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影响因子：
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作者：
Richter, Bernhard;Koller, Lorenz;Niessner, Alexander
通讯作者：
Niessner, Alexander