From transporter to transceptor: signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function.
From transporter to transceptor: signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function.
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DOI：
10.1002/bies.201100100
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发表时间：
2011-11
期刊：
影响因子：
4
通讯作者：
Thevelein, Johan M.
中科院分区：
文献类型：
--
作者：
Kriel, Johan;Haesendonckx, Steven;Rubio-Texeira, Marta;Van Zeebroeck, Griet;Thevelein, Johan M.
当细胞缺乏底物时，许多营养转运蛋白被诱导。当它们的底物再次可用时，它们经历快速的内吞作用和细胞内运输的重定向。这些转运蛋白中的一些也充当受体或受体，这一发现表明，至少部分控制这些蛋白质运输的复杂控制与它们的信号功能有关，而不是与运输控制有关。在酵母中，一般氨基酸渗透酶Gap1介导蛋白激酶A途径的信号传导。它的内吞内化和细胞内运输受氨基酸控制。控制这一信号转导途径的其他营养受体似乎也受到类似的贩运调节。具有复杂调节控制的转运蛋白也被认为在其他生物体中起受体的作用。因此，对细胞内营养转运蛋白运输的精确调控可能与对营养诱导信号的严格控制有关。
When cells are starved of their substrate, many nutrient transporters are induced. These undergo rapid endocytosis and redirection of their intracellular trafficking when their substrate becomes available again. The discovery that some of these transporters also act as receptors, or transceptors, suggests that at least part of the sophisticated controls governing the trafficking of these proteins has to do with their signaling function rather than with control of transport. In yeast, the general amino acid permease Gap1 mediates signaling to the protein kinase A pathway. Its endocytic internalization and intracellular trafficking are subject to amino acid control. Other nutrient transceptors controlling this signal transduction pathway appear to be subject to similar trafficking regulation. Transporters with complex regulatory control have also been suggested to function as transceptors in other organisms. Hence, precise regulation of intracellular trafficking in nutrient transporters may be related to the need for tight control of nutrient-induced signaling.
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影响因子：
2.6
作者：
DURNEZ, P;PERNAMBUCO, MB;THEVELEIN, JM
通讯作者：
THEVELEIN, JM
影响因子：
--
作者：
Broach, J R;Deschenes, R J
通讯作者：
Deschenes, R J
影响因子：
3.6
作者：
HEIN, C;SPRINGAEL, JY;ANDRE, B
通讯作者：
ANDRE, B
DOI：
10.1073/pnas.232591899
发表时间：
2002-11-12
影响因子：
11.1
作者：
Chen, EJ;Kaiser, CA
通讯作者：
Kaiser, CA
影响因子：
4.8
作者：
De Craene, JO;Soetens, O;André, B
通讯作者：
André, B