Response variability in the visual field: comparison of optic neuritis, glaucoma, ocular hypertension, and normal eyes.
Response variability in the visual field: comparison of optic neuritis, glaucoma, ocular hypertension, and normal eyes.
复制标题
视野反应变异性：视神经炎、青光眼、高眼压症和正常眼睛的比较。
DOI：
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发表时间：
2000
影响因子：
4.4
通讯作者：
Alec Ansons
中科院分区：
文献类型：
--
作者：
David B. Henson;S. Chaudry;P. Artes;E. Faragher;Alec Ansons
目的
比较正常眼与视神经炎（ON）、青光眼（POAG）、高眼压症（OHT）患者视野敏感度和反应变异性的关系。
方法
在Henson 4000视野计（Tinsley Instruments，Croydon，UK）上使用恒定刺激方法，从71名受试者（12名ON，25名POAG，11名OHT和23名正常）的一只眼睛的四个视野位置收集视频（FOS）数据。在每个位置，至少有20个刺激（对向0.5度），在200毫秒以上和低于估计阈值的六个或更多的强度。使用概率单位拟合的累积正态函数的平均值和SD估计灵敏度和响应变异性。进行聚类回归分析，以确定四组之间的敏感性-log（变异性）关系是否存在差异。
结果
发现所有四组的变异性随着灵敏度的降低而增加。四组的合并数据可通过函数log（e）（SD）= A.灵敏度（dB）+ B很好地表示（R2 = 0.57），其中常数A和B分别为-0.081（SE，+/-0.005）和3.27（SE，+/-0.15）。将其他统计学显著协变量（假阴性误差，P = 0.004）和因素（诊断，P = 0.005）纳入模型中，可解释方差的比例增加至62%（R2 = 0.62）。刺激偏心率（P = 0.34）、患者年龄（P = 0.33）、固视丢失率（P = 0.10）和假阳性率（P = 0.66）作为反应变异性的额外预测因子未达到统计学显著性。
结论
ON、POAG、OHT和正常眼的反应变异性和敏感性之间的关系相似。这些结果为反应变异性依赖于功能性神经节细胞密度的假设提供了支持证据。
PURPOSE
To compare the relationship between sensitivity and response variability in the visual field of normal eyes and eyes with optic neuritis (ON), glaucoma (POAG), and ocular hypertension (OHT).
METHODS
Frequency-of-seeing (FOS) data were collected from four visual field locations in one eye of 71 subjects (12 ON, 25 POAG, 11 OHT, and 23 normal), using a constant stimulus method on an Henson 4000 perimeter (Tinsley Instruments, Croydon, UK). At each location, at least 20 stimuli (subtending 0.5 degrees) were presented for 200 ms at six or more intensities above and below the estimated threshold. The mean and SD of the probit fitted cumulative Normal function were used to estimate sensitivity and response variability. Cluster regression analysis was carried out to determine whether there were differences in the sensitivity-log (variability) relationship between the four groups.
RESULTS
Variability was found to increase with decreased sensitivity for all four groups. The combined data from the four groups was well represented (R2 = 0.57) by the function log(e)(SD) = A.sensitivity (dB) + B, where the constants A and B were -0.081 (SE, +/-0.005) and 3.27 (SE, +/-0.15), respectively. Including other statistically significant covariates (false-negative errors, P = 0.004) and factors (diagnosis, P = 0.005) into the model increased the proportion of explained variance to 62% (R2 = 0.62). Stimulus eccentricity (P = 0.34), patient age (P = 0.33), fixation loss rate (P = 0.10), and false-positive rate (P = 0.66) did not reach statistical significance as additional predictors of response variability.
CONCLUSIONS
The relationship between response variability and sensitivity is similar for ON, POAG, OHT, and normal eyes. These results provide supporting evidence for the hypothesis that response variability is dependent on functional ganglion cell density.
正常观察者定量自动视野检查的变异性。
影响因子：
13.7
作者：
Lewis,RA;Johnson,CA;Keltner,JL;Labermeier,PK
通讯作者：
Labermeier,PK
DOI：
10.1001/archopht.1986.01050130075023
发表时间：
1986
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Katz,J;Sommer,A
通讯作者：
Sommer,A