Salinomycin as a drug for targeting human cancer stem cells.
Salinomycin as a drug for targeting human cancer stem cells.
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DOI：
10.1155/2012/950658
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发表时间：
2012
影响因子：
--
通讯作者：
Steinhart R
中科院分区：
文献类型：
--
作者：
Naujokat C;Steinhart R
癌症干细胞（CSC）代表肿瘤细胞的亚群，其具有自我更新和肿瘤起始能力以及产生构成肿瘤的恶性细胞的异质谱系的能力。 CSCs 具有对化疗药物、新型肿瘤靶向药物和放射治疗产生耐药性的多种内在机制，使它们能够在标准癌症治疗中存活并引发肿瘤复发和转移。最近已鉴定出赋予 CSC 抵抗力和存活的各种分子复合物和途径，包括 ATP 结合盒 (ABC) 药物转运蛋白的表达、Wnt/β-连环蛋白、Hedgehog、Notch 和 PI3K/Akt/mTOR 信号通路的激活，以及上皮间质转化 (EMT) 的获得。 Salinomycin 是一种从白色链霉菌中分离出来的聚醚离子载体抗生素，已被证明可以杀死不同类型人类癌症中的 CSC，最有可能是通过干扰 ABC 药物转运蛋白、Wnt/β-连环蛋白信号通路和其他 CSC 通路。人类异种移植小鼠的临床前试验和一些临床试点研究显示，盐霉素能够有效消除 CSC，并诱导经过大量预处理和治疗耐药的癌症的部分临床消退。盐霉素杀死 CSC 和耐药癌细胞的能力可能使该化合物成为一种新型有效的抗癌药物。
Cancer stem cells (CSCs) represent a subpopulation of tumor cells that possess self-renewal and tumor initiation capacity and the ability to give rise to the heterogenous lineages of malignant cells that comprise a tumor. CSCs possess multiple intrinsic mechanisms of resistance to chemotherapeutic drugs, novel tumor-targeted drugs, and radiation therapy, allowing them to survive standard cancer therapies and to initiate tumor recurrence and metastasis. Various molecular complexes and pathways that confer resistance and survival of CSCs, including expression of ATP-binding cassette (ABC) drug transporters, activation of the Wnt/β-catenin, Hedgehog, Notch and PI3K/Akt/mTOR signaling pathways, and acquisition of epithelial-mesenchymal transition (EMT), have been identified recently. Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways. Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. The ability of salinomycin to kill both CSCs and therapy-resistant cancer cells may define the compound as a novel and an effective anticancer drug.
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影响因子：
4.4
作者：
DANFORTH, HD;RUFF, MD;MILLER, RL
通讯作者：
MILLER, RL
鉴定非典型畸胎组织/色肽肿瘤中CD133阳性辐射细胞。
影响因子：
3.7
作者：
Chiou, Shih-Hwa;Kao, Chung-Lan;Chen, Yi-Wei;Chien, Chien-Shu;Hung, Shih-Chieh;Lo, Jeng-Fan;Chen, Yann-Jang;Ku, Hung-Hai;Hsu, Ming-Ta;Wong, Tai-Tong
通讯作者：
Wong, Tai-Tong
影响因子：
29.4
作者：
Bardsley MR;Horváth VJ;Asuzu DT;Lorincz A;Redelman D;Hayashi Y;Popko LN;Young DL;Lomberk GA;Urrutia RA;Farrugia G;Rubin BP;Ordog T
通讯作者：
Ordog T
影响因子：
4.3
作者：
Basu, Devraj;Montone, Kathleen T.;Herlyn, Meenhard
通讯作者：
Herlyn, Meenhard
影响因子：
3.7
作者：
Awad O;Yustein JT;Shah P;Gul N;Katuri V;O'Neill A;Kong Y;Brown ML;Toretsky JA;Loeb DM
通讯作者：
Loeb DM