The power of AAA-ATPases on the road of pre-60S ribosome maturation--molecular machines that strip pre-ribosomal particles.
The power of AAA-ATPases on the road of pre-60S ribosome maturation--molecular machines that strip pre-ribosomal particles.
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DOI：
10.1016/j.bbamcr.2011.06.017
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Bassler J
中科院分区：
文献类型：
--
作者：
Kressler D;Hurt E;Bergler H;Bassler J
核糖体的生物发生是一个基本的细胞过程，它提供了合成所有细胞蛋白质的分子机器。真核生物核糖体的组装是一个高度复杂的多步骤过程，需要200多种核糖体生物合成因子，介导广泛的成熟反应。许多能量消耗酶（例如AAA型ATP酶、RNA解旋酶和GTP酶）参与这一过程表明驱动核糖体组装需要消耗能量。虽然这些酶中的许多的精确功能仍然难以捉摸，但最近的进展已经揭示，参与60 S亚基生物合成的三种AAA型ATP酶专门致力于不同生物合成因子的释放和回收。在这篇综述中，我们将重点介绍如何利用酵母Drg 1，Rix 7和Rea 1的分子动力来促进其底物蛋白从进化的前60 S颗粒中释放，并在适当的情况下讨论可能的催化机制。本文是特刊的一部分，题为：AAA ATP酶：结构和功能。综述了核糖体生物合成中AAA-ATP酶的结构和功能特性。AAA-ATP酶Rea 1、Rix 7和Drg 1是酵母中核糖体生物合成所必需的。Rix 7和Drg 1与Cdc 48相关，而Rea 1与马达蛋白动力蛋白相似。Rea 1、Rix 7和Drg 1促进生物合成因子从核仁、核质和细胞质前60 S中间体释放。AAA-ATP酶释放成熟因子对前60 S颗粒的下游成熟至关重要。
The biogenesis of ribosomes is a fundamental cellular process, which provides the molecular machines that synthesize all cellular proteins. The assembly of eukaryotic ribosomes is a highly complex multi-step process that requires more than 200 ribosome biogenesis factors, which mediate a broad spectrum of maturation reactions. The participation of many energy-consuming enzymes (e.g. AAA-type ATPases, RNA helicases, and GTPases) in this process indicates that the expenditure of energy is required to drive ribosome assembly. While the precise function of many of these enzymes remains elusive, recent progress has revealed that the three AAA-type ATPases involved in 60S subunit biogenesis are specifically dedicated to the release and recycling of distinct biogenesis factors. In this review, we will highlight how the molecular power of yeast Drg1, Rix7, and Rea1 is harnessed to promote the release of their substrate proteins from evolving pre-60S particles and, where appropriate, discuss possible catalytic mechanisms. This article is part of a Special Issue entitled: AAA ATPases: structure and function. ► Structural and functional properties of AAA-ATPases in ribosome biogenesis are summarized. ► The AAA-ATPases Rea1, Rix7 and Drg1 are essential for ribosome biogenesis in yeast. ► Rix7 and Drg1 are related to Cdc48, while Rea1 shares similarity to motor protein dynein. ► Rea1, Rix7 and Drg1 promote the release of biogenesis factors from nucleolar, nucleoplasmic and cytoplasmic pre-60S intermediates. ► The release of maturation factors by AAA-ATPases is critical for downstream maturation of pre-60S particles.
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rRNA 加工和 60S 核糖体亚基的核内运输需要必需的 WD 重复蛋白 Rsa4p。
影响因子：
14.9
作者：
de la Cruz J;Sanz-Martínez E;Remacha M
通讯作者：
Remacha M
DOI：
10.1126/science.1164424
发表时间：
2008-12-12
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2005-08-01
期刊：
The Journal of cell biology
影响因子：
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作者：
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通讯作者：
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DOI：
10.1038/nsb972
发表时间：
2003-10-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
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作者：
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通讯作者：
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影响因子：
4.8
作者：
Galani, K;Nissan, TA;Hurt, E
通讯作者：
Hurt, E