Glycosidase-activated H2S donorsto enhance chemotherapy efficacy.
Glycosidase-activated H2S donorsto enhance chemotherapy efficacy.
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糖苷酶激活的 H2S 供体可增强化疗效果。
DOI：
10.1016/j.bmcl.2024.129644
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发表时间：
2024
影响因子：
2.7
通讯作者：
Jingli Hou
中科院分区：
文献类型：
--
作者：
Zizhen Ye;Jixiang Li;Jiarui Shi;Yuguang Song;Yangping Liu;Jingli Hou
Hydrogen sulfide (H2S) plays a critical role in cancer biology. Herein, we developed a series of glycosidase-triggered hydrogen sulfide (H2S) donors by connecting sugar moieties (including glucose, galactose and mannose) to COS donorsviaa self-immolative spacer. In the presence of corresponding glycosidases, H2S was gradually released from these donors in PBS buffer with releasing efficiencies from 36 to 67 %. H2S release was also detected by H2S probe WSP-1 after treatment HepG2 cells with Man1. Cytotoxicities of these glycosylated H2S donors were evaluated against HepG2 by MTT assay. Among them, Man1 and Man2 exhibited an obvious reduction of cell viability in HepG2 cells, with cell viability as 37.6 % for 80 μM of Man. Consistently, significant apoptosis was observed in HepG2 cells after treatment with Man1 and Man2. Finally, We evaluated the potential of Man1 for combination therapy with doxorubicin. A synergistic effect was observed between Man1 and Doxorubicin in HepG2 and Hela cells. All these results indicated glycosidase-activated H2S donorshave promising potential for cancer therapy.
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影响因子：
8.4
作者：
Calvaresi EC;Hergenrother PJ
通讯作者：
Hergenrother PJ
DOI：
10.1002/anie.201510551
发表时间：
2016-02-12
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Patra M;Johnstone TC;Suntharalingam K;Lippard SJ
通讯作者：
Lippard SJ
影响因子：
10.6
作者：
Mueckler, Mike;Thorens, Bernard
通讯作者：
Thorens, Bernard
DOI：
10.1039/c8cc02428f
发表时间：
2018-05-10
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Zhao Y ;Steiger AK ;Pluth MD
通讯作者：
Pluth MD
影响因子：
6.6
作者：
Yang, Chun-tao;Devarie-Baez, Nelmi O.;Xian, Ming
通讯作者：
Xian, Ming