Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis
Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis
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识别具有高抗性淀粉含量的作物变体以维持健康的葡萄糖稳态
DOI：
10.1111/nbu.12240
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发表时间：
2016
影响因子：
3.3
通讯作者：
Petropoulou K
中科院分区：
文献类型：
--
作者：
Petropoulou K
确定防止胰腺β细胞胰岛素分泌紊乱的饮食工具是对抗2型糖尿病日益增加的患病率的一种有吸引力的策略。膳食抗性淀粉与β细胞功能的改善有关，可能是通过增加结肠发酵和短链脂肪酸（SCFA）的产生。因此，增加常用食物中的抗性淀粉含量可以维持人群水平的葡萄糖稳态。作为生物技术和生物科学研究理事会（BBSRC）饮食和健康研究产业俱乐部（DRINC）倡议的一部分，豌豆的变种。(pea)正在研究豌豆淀粉的特性，这些特性使豌豆淀粉耐消化并可用于结肠发酵和SCFA生产。正在使用整个豌豆种子和豌豆粉进行豌豆素体外和体内研究，以促进更好地了解豌豆子叶中的细胞如何受到加工的影响，以及这如何影响淀粉消化率。人类志愿者试验用于监测与胰腺β细胞功能和葡萄糖稳态相关的全方位短期和长期生理反应。该项目为与特定类型的抗性淀粉相关的作物变体提供了新的见解，这些抗性淀粉为胰岛素分泌和功能缺陷提供了最佳保护。
Identifying dietary tools that prevent disordered insulin secretion from pancreatic β‐cells is an attractive strategy to combat the increasing prevalence of type 2 diabetes. Dietary resistant starch has been linked to improvements in the function of β‐cells, possibly via increased colonic fermentation and production of short‐chain fatty acids (SCFAs). Increasing the resistant starch content of commonly consumed foods could therefore maintain glucose homeostasis at the population level. As part of Biotechnology and Biological Sciences Research Council (BBSRC) Diet and Health Research Industry Club (DRINC) initiative, variants ofPisum sativumL. (pea) are being investigated to identify the features of pea starch that make it resistant to digestion and available for colonic fermentation and SCFA production. Parallelin vitroandin vivostudies are being conducted using both whole pea seeds and pea flour to facilitate a better understanding of how cells in the pea cotyledons are affected by processing and, in turn, how this influences starch digestibility. Trials in human volunteers are being used to monitor a full spectrum of short‐ and long‐term physiological responses relevant to pancreatic β‐cell function and glucose homeostasis. This project is providing new insights into variants of crops that are associated with the specific types of resistant starch that provide the best protection against defects in insulin secretion and function.
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DOI：
10.1172/jci10533
发表时间：
2000-01
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
A. Saltiel
通讯作者：
A. Saltiel
DOI：
10.1152/ajpendo.90637.2008
发表时间：
2008-11-01
影响因子：
5.1
作者：
Zhou, June;Martin, Roy J.;Keenan, Michael J.
通讯作者：
Keenan, Michael J.
影响因子：
--
作者：
Jenkins, David J. A.;Kendall, Cyril W. C.;Josse, Robert G.
通讯作者：
Josse, Robert G.
影响因子：
5.8
作者：
Robertson, M. Denise;Wright, John W.;Umpleby, A. Margot
通讯作者：
Umpleby, A. Margot
肥胖中的β细胞功能：减肥的影响。
影响因子：
7.7
作者：
E. Ferrannini;S. Camastra;A. Gastaldelli;Anna Maria Sironi;A. Natali;E. Muscelli;G. Mingrone;A. Mari
通讯作者：
A. Mari