The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease.
The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease.
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DOI：
10.3389/fcvm.2021.701224
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发表时间：
2021
影响因子：
3.6
通讯作者：
Grande-Allen KJ
中科院分区：
文献类型：
--
作者：
Jui E;Singampalli KL;Shani K;Ning Y;Connell JP;Birla RK;Bollyky PL;Caldarone CA;Keswani SG;Grande-Allen KJ
患有后天性心脏病的儿童面临着重大的健康挑战，包括终身严格的医疗管理，多次心脏手术和高死亡率风险。虽然这些疾病的表现是多种多样的，但一个统一的因素是免疫和炎症反应在其发展和/或进展中的作用。例如，传染性病原体与儿科心血管疾病有关，导致巨大的健康负担，不成比例地影响低收入地区。其他涉及的机制包括抗体靶向心脏蛋白、心脏细胞感染和炎症介导的心脏结构损伤。这些变化可以改变血流模式，改变细胞外基质组成，并诱导心脏重塑。因此，了解免疫系统与心血管疾病之间的关系可以为有针对性的诊断和治疗方法提供信息。在这篇综述中，我们讨论了目前对儿科免疫相关心脏病的理解，该领域的挑战以及具有临床益处潜力的研究领域。
Children with acquired heart disease face significant health challenges, including a lifetime of strict medical management, multiple cardiac surgeries, and a high mortality risk. Though the presentation of these conditions is diverse, a unifying factor is the role of immune and inflammatory responses in their development and/or progression. For example, infectious agents have been linked to pediatric cardiovascular disease, leading to a large health burden that disproportionately affects low-income areas. Other implicated mechanisms include antibody targeting of cardiac proteins, infection of cardiac cells, and inflammation-mediated damage to cardiac structures. These changes can alter blood flow patterns, change extracellular matrix composition, and induce cardiac remodeling. Therefore, understanding the relationship between the immune system and cardiovascular disease can inform targeted diagnostic and treatment approaches. In this review, we discuss the current understanding of pediatric immune-associated cardiac diseases, challenges in the field, and areas of research with potential for clinical benefit.
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