Malaria parasite species composition of Plasmodium infections among asymptomatic and symptomatic school-age children in rural and urban areas of Kinshasa, Democratic Republic of Congo.
Malaria parasite species composition of Plasmodium infections among asymptomatic and symptomatic school-age children in rural and urban areas of Kinshasa, Democratic Republic of Congo.
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DOI：
10.1186/s12936-021-03919-4
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发表时间：
2021-10-02
期刊：
影响因子：
3
通讯作者：
Yamamoto T
中科院分区：
文献类型：
--
作者：
Nundu SS;Culleton R;Simpson SV;Arima H;Muyembe JJ;Mita T;Ahuka S;Yamamoto T
疟疾仍然是刚果民主共和国 (DRC) 的一个主要公共卫生问题，学龄儿童在疟疾患病率调查中相对被忽视，可能构成重要的传播库。本研究旨在了解金沙萨/刚果民主共和国学龄儿童的疟疾感染负担。通过显微镜、RDT 和巢式 PCR 分析了从 6 岁至 14 岁学龄儿童收集的总共 634 份（427 份无症状和 207 份有症状）血液样本。疟原虫属的总体流行率。通过显微镜、RDT 和 PCR 检测，无症状儿童中的诊断率分别为 33%、42% 和 62%，有症状儿童中的诊断率分别为 59%、64% 和 95%。恶性疟原虫、三日疟原虫和卵形疟原虫的流行情况。在无症状儿童中，PCR 检测结果分别为 58%、20% 和 11%，在有症状儿童中分别为 93%、13% 和 16%。在卵形 P. ovale spp. 中，P. ovale curtisi、P. ovale wallikeri 和混合 P. ovale curtisi + P. ovale wallikeri 分别占感染的 75%、24% 和 1%。与城市地区的无症状感染者相比，所有疟原虫种类感染在农村地区的发病率明显更高（p<0.001）。与城市地区相比，生活在农村地区携带无症状疟疾寄生虫的风险高出五倍（p<0.001）。在无症状疟原虫携带者中，农村和城市地区分别有43%和16%的儿童携带疟原虫和恶性疟原虫混合感染，而在有症状的疟疾感染中，这一比例分别为22%和26%。很少有儿童单一感染三日疟原虫 (2.2%) 和卵形疟原虫。 （1.9%）。学龄儿童面临无症状和有症状疟疾感染的巨大风险。需要对高传播环境中的学龄儿童进行持续的系统筛查和治疗。在线版本包含可在 10.1186/s12936-021-03919-4 获取的补充材料。
Malaria remains a major public health concern in the Democratic Republic of Congo (DRC), and school-age children are relatively neglected in malaria prevalence surveys and may constitute a significant reservoir of transmission. This study aimed to understand the burden of malaria infections in school-age children in Kinshasa/DRC. A total of 634 (427 asymptomatic and 207 symptomatic) blood samples collected from school-age children aged 6 to 14 years were analysed by microscopy, RDT and Nested-PCR. The overall prevalence of Plasmodium spp. by microscopy, RDT and PCR was 33%, 42% and 62% among asymptomatic children and 59%, 64% and 95% in symptomatic children, respectively. The prevalence of Plasmodium falciparum, Plasmodium malariae and Plasmodium ovale spp. by PCR was 58%, 20% and 11% among asymptomatic and 93%, 13% and 16% in symptomatic children, respectively. Among P. ovale spp., P. ovale curtisi, P. ovale wallikeri and mixed P. ovale curtisi + P. ovale wallikeri accounted for 75%, 24% and 1% of infections, respectively. All Plasmodium species infections were significantly more prevalent in the rural area compared to the urban area in asymptomatic infections (p < 0.001). Living in a rural as opposed to an urban area was associated with a five-fold greater risk of asymptomatic malaria parasite carriage (p < 0.001). Amongst asymptomatic malaria parasite carriers, 43% and 16% of children harboured mixed Plasmodium with P. falciparum infections in the rural and the urban areas, respectively, whereas in symptomatic malaria infections, it was 22% and 26%, respectively. Few children carried single infections of P. malariae (2.2%) and P. ovale spp. (1.9%). School-age children are at significant risk from both asymptomatic and symptomatic malaria infections. Continuous systematic screening and treatment of school-age children in high-transmission settings is needed. The online version contains supplementary material available at 10.1186/s12936-021-03919-4.
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影响因子：
3
作者：
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影响因子：
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