Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection.
Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection.
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清道夫受体A调节对肺隐孢子菌感染的免疫反应。
DOI：
10.4049/jimmunol.1203435
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发表时间：
2013-07-01
期刊：
影响因子：
--
通讯作者：
Olszewski MA
中科院分区：
文献类型：
--
作者：
Qiu Y;Dayrit JK;Davis MJ;Carolan JF;Osterholzer JJ;Curtis JL;Olszewski MA
清道夫受体代表一类重要的模式识别受体，其在宿主防御微生物病原体中介导有益和有害的作用。主要的巨噬细胞清道夫受体，清道夫受体A（SRA），在对病原性真菌，新型隐球菌的免疫应答中的作用是未知的。为了评估SRA在抗隐球菌宿主防御中的作用，将SRA+/+小鼠和SRA−/−小鼠用C.新人类结果表明，与SRA+/+小鼠相比，SRA−/−小鼠的感染导致传出相（3周）肺真菌负荷减少。SRA-/-小鼠中真菌清除率的提高与嗜酸性粒细胞积聚的减少以及CD 4 + T细胞和CD 11b+树突状细胞积聚的增加有关。其他参数与感染的SRA−/−小鼠中增强的抗隐球菌免疫力一致：1）增加肺APC的共刺激分子CD 80和CD 86的表达，2）减少Th 2细胞因子的表达，（IL-4和IL-13）和IL-10在肺白细胞和隐球菌Ag-脉冲脾细胞，3）减少IgE的产生，和4）增加的典型肺巨噬细胞活化的标志。这些影响之前，在传入阶段（1周）的肺淋巴结中的早期前Th 1基因的表达增加。总的来说，我们的数据表明，SRA可以被C。新生儿干扰支持Th 1免疫极化的传入反应的早期事件。这导致免疫应答的Th 2臂的扩增，并随后损害C.感染的肺部有新生儿
Scavenger receptors represent an important class of pattern recognition receptors shown to mediate both beneficial and detrimental roles in host defense against microbial pathogens. The role of the major macrophage scavenger receptor, scavenger receptor A (SRA), in the immune response against the pathogenic fungus, Cryptococcus neoformans, is unknown. To evaluate the role of SRA in anticryptococcal host defenses, SRA+/+ mice and SRA−/− mice were infected intratracheally with C. neoformans. Results show that infection of SRA−/− mice resulted in a reduction in the pulmonary fungal burden at the efferent phase (3 wk) compared with SRA+/+ mice. Improved fungal clearance in SRA−/− mice was associated with decreased accumulation of eosinophils and greater accumulation of CD4+ T cells and CD11b+ dendritic cells. Additional parameters were consistent with enhanced anti-cryptococcal immunity in the infected SRA−/− mice: 1) increased expression of the costimulatory molecules CD80 and CD86 by lung APCs, 2) decreased expression of Th2 cytokines (IL-4 and IL-13) and IL-10 in lung leukocytes and in cryptococcal Ag-pulsed splenocytes, 3) diminished IgE production in sera, and 4) increased hallmarks of classical pulmonary macrophage activation. These effects were preceded by increased expression of early pro-Th1 genes in pulmonary lymph nodes at the afferent phase (1 wk). Collectively, our data show that SRA can be exploited by C. neoformans to interfere with the early events of the afferent responses that support Th1 immune polarization. This results in amplification of Th2 arm of the immune response and subsequently impaired adaptive control of C. neoformans in the infected lungs.
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影响因子：
6
作者：
Ishiguro, T;Naito, M;Kodama, T
通讯作者：
Kodama, T
影响因子：
5.5
作者：
HUFFNAGLE, GB;LIPSCOMB, MF;STREET, NE
通讯作者：
STREET, NE
影响因子：
6
作者：
He, Xiumiao;Lyons, Daniel M.;Olszewski, Michal A.
通讯作者：
Olszewski, Michal A.
DOI：
10.1038/nrmicro2522
发表时间：
2011-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Kronstad JW;Attarian R;Cadieux B;Choi J;D'Souza CA;Griffiths EJ;Geddes JM;Hu G;Jung WH;Kretschmer M;Saikia S;Wang J
通讯作者：
Wang J
DOI：
10.1126/science.1183021
发表时间：
2010-01-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iwasaki A;Medzhitov R
通讯作者：
Medzhitov R