Possibility evaluation of the optical imaging of proton mini-beams
Possibility evaluation of the optical imaging of proton mini-beams
复制标题
质子微型束流光学成像的可能性评估
DOI：
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发表时间：
2021
影响因子：
3.5
通讯作者：
T. Akagi
中科院分区：
文献类型：
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作者：
S. Yamamoto;T. Yabe;T. Akagi
使用微束的质子治疗是减少对正常组织的辐射损伤的有前途的方法。然而，由于微梁的小结构，其分布测量是困难的。由于光学成像是一种可能的方法来测量高分辨率的二维剂量分布，我们进行了光学成像的丙烯酸块在照射的质子的迷你束。微型束是由质子笔形束照射到由钨板制成的1mm狭缝上制成的。在照射的丙烯酸块的小光束，我们测量的丙烯酸块的发光使用电荷耦合器件相机。通过测量，我们可以获得在浅区域具有狭缝形状的狭缝光束图像，同时它们的布拉格峰是均匀的，这类似于通过蒙特卡罗模拟的模拟光学图像的情况。我们证实了微束的高分辨率光学成像是可能的，并为微束的有效质量评估以及微束治疗的研究提供了一种有前途的方法。
Proton therapy using mini-beams is a promising method to reduce radiation damage to normal tissue. However, distribution measurements of mini-beams are difficult due to their small structures. Since optical imaging is a possible method to measure high-resolution two-dimensional dose distribution, we conducted optical imaging of an acrylic block during the irradiation of mini-beams of protons. Mini-beams were made from a proton pencil beam irradiated to 1 mm slits made of tungsten plate. During irradiation of the mini-beams to the acrylic block, we measured the luminescence of the acrylic block using a charge-coupled device camera. With the measurements, we could obtain slit beam images that have slit shapes in the shallow area while they were uniform in their Bragg peaks, which was similar to the case of simulated optical images by Monte Carlo simulations. We confirmed that high-resolution optical imaging of mini-beams is possible and provides a promising method for efficient quality assessment of mini-beams as well as research on mini-beam therapy.
影响因子：
3.6
作者：
Glaser AK;Voigt WH;Davis SC;Zhang R;Gladstone DJ;Pogue BW
通讯作者：
Pogue BW